CD80 Gene Summary [Human]
The protein encoded by this gene is a membrane receptor that is activated by the binding of CD28 or CTLA-4. The activated protein induces T-cell proliferation and cytokine production. This protein can act as a receptor for adenovirus subgroup B and may play a role in lupus neuropathy. [provided by RefSeq, Aug 2011]
Details
| Type | Protein Coding |
| Official Symbol | CD80 |
| Official Name | CD80 molecule [Source:HGNC Symbol;Acc:HGNC:1700] |
| Ensembl ID | ENSG00000121594 |
| Bio databases IDs | |
| Aliases | CD80 molecule, B-lymphocyte activation antigen B7 |
| Synonyms | B7, B7-1, B7.1, BB1, Cd28l, CD28LG, CD28LG1, CD80 antigen, CD80 molecule, LAB7, LOC100360171, Ly-53, MIC17, TSA1 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human CD80 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- extracellular domain
- cytoplasmic domain
- Immunoglobulin V-Type
- immunoglobulin domain
- transmembrane domain
- Immunoglobulin like
- receptor agonist activity
- protein binding
- cytosolic tail domain
- transmembrane receptor
- Immunoglobulin V-set domain
Pathways
Biological processes and signaling networks where the CD80 gene in human plays a role, providing insight into its function and relevance in health or disease.
- Allograft Rejection Signaling
- Altered T Cell and B Cell Signaling in Rheumatoid Arthritis
- Autoimmune Thyroid Disease Signaling
- B Cell Development
- Communication between Innate and Adaptive Immune Cells
- Crosstalk between Dendritic Cells and Natural Killer Cells
- CTLA4 Signaling in Cytotoxic T Lymphocytes
- Dendritic Cell Maturation
- Graft-versus-Host Disease Signaling
- IL-10 Signaling
- Neuroinflammation Signaling Pathway
- Nur77 Signaling in T Lymphocytes
- PKCθ Signaling in T Lymphocytes
- Regulation of IL-2 Expression in Activated and Anergic T Lymphocytes
- Systemic Lupus Erythematosus Signaling
- T Cell Receptor Signaling
- T Helper Cell Differentiation
- Th1 and Th2 Activation Pathway
- Th1 Pathway
- Th2 Pathway
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- end stage renal disease
- neoplasia
- metastasis
- moderate active ulcerative colitis
- epithelial cancer
- experimental autoimmune encephalomyelitis
- rheumatoid arthritis
- psoriatic arthritis
- septic shock
- Crohn disease
regulated by
- tumor cells
- S-(2,3-bispalmitoyloxypropyl)-cysteine-GDPKHPKSF
- lipopolysaccharide
- Sudan ebolavirus
- sirolimus
- ARL6IP1
- fingolimod
- E7
- heparin
- TLR
role in cell
- quantity
- expression in
- apoptosis
- activation
- activation in
- growth
- proliferation
- number
- cellular infiltration by
- differentiation
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- cell surface
- intracellular space
- membrane surface
- cellular membrane
- endosomes
- plasma membrane extracellular face
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human CD80 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- viral entry into host cell
- positive regulation of T-helper 1 cell differentiation
- T cell costimulation
- T cell activation
- cell surface receptor signaling pathway
- positive regulation of T cell proliferation
- positive regulation of signal transduction
- negative regulation of T cell mediated immunity
- immune response
- positive regulation of granulocyte macrophage colony-stimulating factor production
- cellular response to lipopolysaccharide
- positive regulation of transcription, DNA-dependent
- negative regulation of T cell proliferation
- positive regulation of peptidyl-tyrosine phosphorylation
- intracellular signal transduction
- positive regulation of interleukin-2 production
Cellular Component
Where in the cell the gene product is active
- external side of plasma membrane
- plasma membrane
- cell surface
Molecular Function
What the gene product does at the molecular level
- coreceptor activity
- protein binding
- receptor agonist activity
- viral receptor activity