TELO2 Gene Summary [Human]
This gene encodes a protein that functions as an S-phase checkpoint protein in the cell cycle. The protein may also play a role in DNA repair.[provided by RefSeq, Mar 2009]
Details
| Type | Nonsense Mediated Decay |
| Official Symbol | TELO2 |
| Official Name | telomere maintenance 2 [Source:HGNC Symbol;Acc:HGNC:29099] |
| Ensembl ID | ENSG00000100726 |
| Bio databases IDs | |
| Aliases | telomere maintenance 2 |
| Synonyms | 1200003M09Rik, AI415602, CLK2, mKIAA0683, RGD1305553, TEL2, telomere maintenance 2, YHFS |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human TELO2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- kinase binding
- binding protein
- protein kinase binding
- heat shock protein binding
- Telomere length regulation protein
- protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Nucleus
- cytosol
- nuclear bodies
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human TELO2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- positive regulation of DNA damage checkpoint
- 'de novo' cotranslational protein folding
- protein stabilization
Cellular Component
Where in the cell the gene product is active
- nucleus
- chromosome, telomeric region
- nuclear body
- cytoplasm
- membrane
- cytosol
Molecular Function
What the gene product does at the molecular level
- protein kinase binding
- protein binding
- telomeric DNA binding
- Hsp90 protein binding
- binding, bridging