SHFL Gene Summary [Human]
This gene is an interferon stimulated gene (ISG) that inhibits viral replication. The encoded protein binds nucleic acids and inhibits programmed -1 ribosomal frameshifting required for translation by many RNA viruses. Viruses inhibited by the protein include Zika virus, dengue virus and the coronaviruses, SARS-CoV and SARS-CoV2. [provided by RefSeq, Aug 2021]
Details
| Type | Retained Intron |
| Official Symbol | SHFL |
| Official Name | shiftless antiviral inhibitor of ribosomal frameshifting [Source:HGNC Symbol;Acc:HGNC:25649] |
| Ensembl ID | ENSG00000130813 |
| Bio databases IDs | |
| Aliases | shiftless antiviral inhibitor of ribosomal frameshifting, repressor of yield of Dengue virus, interferon-regulated antiviral gene, shiftless |
| Synonyms | A230050P20Rik, C19orf66, FLJ11286, IRAV, RyDEN, SFL, shiftless antiviral inhibitor of ribosomal frameshifting |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human SHFL often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- mRNA binding
- Uncharacterized protein UPF0515
- ribosome binding
- protein binding
- identical protein binding
- RNA binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- cytoplasmic mRNA processing body
- Cytoplasm
- Nucleus
- cytosol
- nucleoplasm
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human SHFL gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- regulation of translational termination
- response to type III interferon
- response to interferon-gamma
- innate immune response
- response to type I interferon
- defense response to virus
- response to interferon-beta
- negative regulation of viral genome replication
- negative regulation of translational frameshifting
Cellular Component
Where in the cell the gene product is active
- nucleus
- cytoplasm
- cytosol
- cytoplasmic mRNA processing body
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- protein binding
- RNA binding
- ribosome binding