Shfl Gene Summary [Mouse]
Predicted to enable identical protein binding activity; ribosome binding activity; and sequence-specific mRNA binding activity. Predicted to be involved in several processes, including defense response to other organism; regulation of translation; and viral translational frameshifting. Predicted to be located in P-body; cytosol; and nucleoplasm. Is expressed in midbrain. Orthologous to human SHFL (shiftless antiviral inhibitor of ribosomal frameshifting). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Shfl |
| Official Name | shiftless antiviral inhibitor of ribosomal frameshifting [Source:MGI Symbol;Acc:MGI:2441788] |
| Ensembl ID | ENSMUSG00000038884 |
| Bio databases IDs | |
| Aliases | shiftless antiviral inhibitor of ribosomal frameshifting |
| Synonyms | A230050P20Rik, C19orf66, FLJ11286, IRAV, RyDEN, SFL, shiftless antiviral inhibitor of ribosomal frameshifting |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Shfl often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- mRNA binding
- Uncharacterized protein UPF0515
- ribosome binding
- protein binding
- identical protein binding
- RNA binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- cytoplasmic mRNA processing body
- Cytoplasm
- Nucleus
- cytosol
- nucleoplasm
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Shfl gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- regulation of translational termination
- response to type III interferon
- response to interferon-gamma
- innate immune response
- response to type I interferon
- defense response to virus
- response to interferon-beta
- negative regulation of viral genome replication
- negative regulation of translational frameshifting
Cellular Component
Where in the cell the gene product is active
- nucleus
- cytoplasm
- cytosol
- cytoplasmic mRNA processing body
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- protein binding
- RNA binding
- ribosome binding