KLF15 Gene Summary [Human]
Enables DNA-binding transcription activator activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in negative regulation of peptidyl-lysine acetylation and positive regulation of transcription by RNA polymerase II. Located in nuclear speck. [provided by Alliance of Genome Resources, Apr 2022]
Details
| Type | Protein Coding |
| Official Symbol | KLF15 |
| Official Name | Kruppel like factor 15 [Source:HGNC Symbol;Acc:HGNC:14536] |
| Ensembl ID | ENSG00000163884 |
| Bio databases IDs | |
| Aliases | Kruppel like factor 15, KLF transcription factor 15, kidney-enriched Kruppel-like factor |
| Synonyms | 1810013I09Rik, CKLF, hlb444, KKLF, KLF transcription factor 15, Kruppel-like transcription factor 15 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human KLF15 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Zinc finger, C2H2 type
- RNA polymerase II transcription regulatory region sequence-specific binding transcriptional activator activity
- transcription regulator
- nucleic acid binding
- protein binding
- sequence-specific DNA binding
- C2H2-type zinc finger
- DNA binding
- RNA polymerase II transcription factor activity, sequence-specific DNA binding
- zinc finger
- double-stranded DNA binding
- Zinc-finger double domain
- transcription factor activity
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- diabetes mellitus
- focal segmental glomerulosclerosis
- colon adenocarcinoma
- colon epithelial cancer
- amyotrophic lateral sclerosis
- heart failure
- colorectal cancer
- breast carcinoma
- androgenic alopecia
role in cell
- apoptosis
- expression in
- phosphorylation in
- proliferation
- binding in
- activation in
- invasion by
- migration
- differentiation
- quantity
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- nuclear fraction
- intracellular membrane-bounded organelle
- nucleoplasm
- nuclear speckles
- chromatin
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human KLF15 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- response to insulin stimulus
- cellular glucose homeostasis
- negative regulation of peptidyl-lysine acetylation
- glomerular visceral epithelial cell differentiation
- positive regulation of glucose import
- regulation of Wnt receptor signaling pathway
- positive regulation of transcription from RNA polymerase II promoter
- glial cell differentiation
- cardiac muscle hypertrophy in response to stress
- regulation of transcription from RNA polymerase II promoter
Cellular Component
Where in the cell the gene product is active
- nucleus
- nuclear speck
- intracellular membrane-bounded organelle
- chromatin
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- protein binding
- metal ion binding
- RNA polymerase II core promoter proximal region sequence-specific DNA binding
- RNA polymerase II regulatory region sequence-specific DNA binding
- transcription regulatory region sequence-specific DNA binding
- RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
- sequence-specific DNA binding RNA polymerase II transcription factor activity