IFNL1 Gene Summary [Human]
This gene encodes a cytokine distantly related to type I interferons and the IL-10 family. This gene, interleukin 28A (IL28A), and interleukin 28B (IL28B) are three closely related cytokine genes that form a cytokine gene cluster on a chromosomal region mapped to 19q13. Expression of the cytokines encoded by the three genes can be induced by viral infection. All three cytokines have been shown to interact with a heterodimeric class II cytokine receptor that consists of interleukin 10 receptor, beta (IL10RB) and interleukin 28 receptor, alpha (IL28RA). [provided by RefSeq, Jul 2008]
Details
| Type | Protein Coding |
| Official Symbol | IFNL1 |
| Official Name | interferon lambda 1 [Source:HGNC Symbol;Acc:HGNC:18363] |
| Ensembl ID | ENSG00000182393 |
| Bio databases IDs | |
| Aliases | interferon lambda 1 |
| Synonyms | IFN LAMBDA 1, IFN-λ 1, IL-29, interferon lambda 1, interferon λ 1 |
| Species | Human, Homo sapiens |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human IFNL1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- hematopoietin/interferon-class (D200-domain) cytokine receptor ligand
- receptor binding
- cytokine
- Interleukin-28A
Pathways
Biological processes and signaling networks where the IFNL1 gene in human plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- colorectal cancer
- viral respiratory infection
- systemic lupus erythematosus
- chronic hepatitis C
- infection by virus
- infection by Human coronavirus OC43
- infection by Influenza A virus
role in cell
- migration
- apoptosis
- expression in
- production in
- cell death
- proliferation
- activation in
- inhibition in
- phosphorylation in
- differentiation
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Extracellular Space
- cell surface
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human IFNL1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of cell proliferation
- positive regulation of tyrosine phosphorylation of STAT protein
- positive regulation of MHC class I biosynthetic process
- JAK-STAT cascade
- positive regulation of JAK-STAT cascade
- negative regulation of T cell differentiation
- negative regulation of memory T cell differentiation
- negative regulation of interleukin-5 production
- negative regulation of transcription, DNA-dependent
- positive regulation of transcription, DNA-dependent
- innate immune response
- positive regulation of interferon-gamma production
- negative regulation of interleukin-13 production
- defense response to virus
- negative regulation of type 2 immune response
- positive regulation of immune response
Cellular Component
Where in the cell the gene product is active
- extracellular space
- interleukin-28 receptor complex
- extracellular region
Molecular Function
What the gene product does at the molecular level
- interleukin-28 receptor binding
- cytokine activity
- receptor binding