PDLIM4 Gene Summary [Human]
Enables alpha-actinin binding activity; protein homodimerization activity; and protein phosphatase binding activity. Involved in actin cytoskeleton reorganization. Located in several cellular components, including lamellipodium; perinuclear region of cytoplasm; and stress fiber. Part of filamentous actin. Implicated in osteoporosis. [provided by Alliance of Genome Resources, Apr 2022]
Details
| Type | Retained Intron |
| Official Symbol | PDLIM4 |
| Official Name | PDZ and LIM domain 4 [Source:HGNC Symbol;Acc:HGNC:16501] |
| Ensembl ID | ENSG00000131435 |
| Bio databases IDs | |
| Aliases | PDZ and LIM domain 4 |
| Synonyms | H-Rev18, LIM protein RIL, PDZ and LIM domain 4, Reversion induced lim, RIL |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human PDLIM4 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Domain of unknown function (DUF4749)
- Domain present in PSD-95, Dlg, and ZO-1/2
- LIM is a small protein-protein interaction domain, containing two zinc fingers
- protein phosphatase binding
- actinin binding
- protein homodimerization
- canonical PDZ domain
- linker domain
- protein binding
- PDZ domain
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- breast cancer
- osteoporosis
- experimentally-induced diabetes
- psoriasis
role in cell
- apoptosis
- growth
- degradation in
- organization
- assembly
- clonogenicity
- organization in
- motility
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- postsynaptic density (PSD) fractions
- membrane fraction
- glutaminergic synapse
- cytoskeleton
- Cytoplasm
- perinuclear region
- actin cytoskeleton
- Nucleus
- endosomes
- actin filaments
- cytosol
- apical cell surfaces
- postsynaptic membrane
- dendritic spines
- actin stress fibers
- postsynaptic density
- lamellipodia
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human PDLIM4 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- heart development
- muscle structure development
- actin cytoskeleton organization
Cellular Component
Where in the cell the gene product is active
- early endosome membrane
- Z disc
- nucleus
- adherens junction
- cytoskeleton
- perinuclear region of cytoplasm
- early endosome lumen
- postsynaptic membrane
- cytoplasm
- dendritic spine
- stress fiber
- recycling endosome membrane
- filamentous actin
- recycling endosome lumen
- lamellipodium
Molecular Function
What the gene product does at the molecular level
- protein binding
- protein homodimerization activity
- protein phosphatase binding
- actin binding
- metal ion binding
- muscle alpha-actinin binding
- alpha-actinin binding