ISG15 Gene Summary [Human]
The protein encoded by this gene is a ubiquitin-like protein that is conjugated to intracellular target proteins upon activation by interferon-alpha and interferon-beta. Several functions have been ascribed to the encoded protein, including chemotactic activity towards neutrophils, direction of ligated target proteins to intermediate filaments, cell-to-cell signaling, and antiviral activity during viral infections. While conjugates of this protein have been found to be noncovalently attached to intermediate filaments, this protein is sometimes secreted. [provided by RefSeq, Dec 2012]
Details
| Type | Protein Coding |
| Official Symbol | ISG15 |
| Official Name | ISG15 ubiquitin like modifier [Source:HGNC Symbol;Acc:HGNC:4053] |
| Ensembl ID | ENSG00000187608 |
| Bio databases IDs | |
| Aliases | ISG15 ubiquitin like modifier |
| Synonyms | G1P2, Gip2, hUCRP, HUMIFN15K, IFI15, IFI-15K, IFN15/17, IFN-alpha-INDUCIBLE, IFN-INDUCIBLE protein 15 KD, IFN-α-INDUCIBLE, IGI15, IMD38, INTERFERON-INDUCED 17-KDA, INTERFERON-STIMULATED protein 15 KDa, IP17, Irfp, Isg15/17, ISG15 ubiquitin-like modifier, LOC100044225, UCRP |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human ISG15 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Ubiquitin family
- diglycine motif
- Ubl1_cv_Nsp3_N-like
- integrin binding
- hinge domain
- Ubiquitin homologues
- protein binding
Pathways
Biological processes and signaling networks where the ISG15 gene in human plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- metastasis
- prostate cancer
- experimental autoimmune encephalomyelitis
- Huntington disease
- liver cancer
- relapsing-remitting multiple sclerosis
- cutaneous T-cell lymphoma
- T-cell non-Hodgkin disease
- mature T-cell neoplasia
role in cell
- synthesis in
- migration
- proliferation
- invasion by
- activation in
- quantity
- expression in
- apoptosis
- differentiation
- degradation in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Extracellular Space
- Nucleus
- intermediate filaments
- cytosol
- plasma membrane projections
- nucleoplasm
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human ISG15 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- positive regulation of protein oligomerization
- ISG15-protein conjugation
- response to type I interferon
- negative regulation of type I interferon-mediated signaling pathway
- response to virus
- positive regulation of erythrocyte differentiation
- defense response to bacterium
- regulation of interferon-gamma production
- integrin-mediated signaling pathway
- protein localization in mitochondrion
- positive regulation of interferon-beta production
- innate immune response
- positive regulation of interferon-gamma production
- defense response to virus
- negative regulation of protein ubiquitination
- positive regulation of interleukin-10 production
- modification-dependent protein catabolic process
- negative regulation of viral genome replication
- positive regulation of bone mineralization
- protein ubiquitination
Cellular Component
Where in the cell the gene product is active
- nucleus
- cytoplasm
- cytosol
- extracellular region
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- protein binding
- ubiquitin protein ligase binding
- integrin binding
- protein tag