MAPK9

MAPK9 Gene Summary

The protein encoded by this gene is a member of the MAP kinase family. MAP kinases act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development. This kinase targets specific transcription factors, and thus mediates immediate-early gene expression in response to various cell stimuli. It is most closely related to MAPK8, both of which are involved in UV radiation induced apoptosis, thought to be related to the cytochrome c-mediated cell death pathway. This gene and MAPK8 are also known as c-Jun N-terminal kinases. This kinase blocks the ubiquitination of tumor suppressor p53, and thus it increases the stability of p53 in nonstressed cells. Studies of this gene's mouse counterpart suggest a key role in T-cell differentiation. Several alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq, Sep 2008]

Details

Type
Protein Coding
Official Symbol
MAPK9
Official Name
mitogen-activated protein kinase 9 [Source:HGNC Symbol;Acc:HGNC:6886]
Ensembl ID
ENSG00000050748
Bio databases IDs NCBI: 5601 Ensembl: ENSG00000050748
Aliases mitogen-activated protein kinase 9, Jun kinase
Synonyms
JNK2,JNK2A,JNK2ALPHA,JNK2B,JNK-55,Jnk p54,Jnk p55,mitogen-activated protein kinase 9,p54a,p54aSAPK,PRKM9,SAPK,SAPK1a,Sapk α
Species
Human, Homo sapiens

Protein Domains

A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
  • protein interaction domain
  • protein serine/threonine kinase
  • protein kinase
  • protein threonine/tyrosine kinase
  • protein kinase binding
  • ATP binding
  • caspase activator
  • protein binding
  • alpha domain
  • Protein kinase domain
  • phosphorylation site
  • kinase
  • Serine/Threonine protein kinases, catalytic domain
  • Protein Kinases, catalytic domain
  • JUN kinase
  • alcohol group acceptor phosphotransferase

Top Findings

The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
binds
  • EGFR
  • WDR62
  • DHX33
  • CDC42
  • JUND
  • KPNA3
  • PRKDC
  • MAPK9
  • JUNB
  • HSPA8
disease
  • neoplasia
  • epithelial neoplasia
  • benign neoplasia
  • non-small cell lung carcinoma
  • cancer
  • epithelial cancer
  • metastatic colon cancer
  • metastatic rectal cancer
  • advanced colon cancer
  • cutaneous melanoma
regulated by
  • CD3 (complex)
  • MAP2K7
  • etoposide
  • TNF
  • Exendin4
  • MAP3K1
  • palmitic acid
  • IFNG
  • tetradecanoylphorbol acetate
  • TCR (complex)
regulates
  • JUN
  • NFkB (complex)
  • PPARG
  • MYC
  • EIF4E
  • CASP8
  • TP53
  • CASP3
  • CDKN1A
  • CASP7
role in cell
  • proliferation
  • phosphorylation in
  • apoptosis
  • expression in
  • transformation
  • number
  • binding in
  • accumulation in
  • colony formation
  • growth

Subcellular Expression

Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
  • Cytoplasm
  • Nucleus
  • Plasma Membrane
  • Mitochondria
  • cytosol
  • nucleoplasm
  • nuclear speckles
  • synapse
  • perikaryon

Gene Ontology Annotations

Describes the biological processes, cellular components, and molecular functions associated with the MAPK9 gene, providing context for its role in the cell.

BIOLOGICAL PROCESS

Functions and activities the gene product is involved in
  • cellular senescence
  • Fc-epsilon receptor signaling pathway
  • apoptotic signaling pathway
  • JNK cascade
  • regulation of circadian rhythm
  • protein phosphorylation
  • positive regulation of cytokine production involved in inflammatory response
  • rhythmic process
  • positive regulation of gene expression
  • cellular response to cadmium ion
  • positive regulation of protein ubiquitination
  • regulation of synaptic transmission
  • positive regulation of macrophage derived foam cell differentiation
  • positive regulation of proteasomal ubiquitin-dependent protein catabolic process
  • cellular response to reactive oxygen species
  • positive regulation of podosome assembly
  • positive regulation of apoptotic signaling pathway

CELLULAR COMPONENT

Where in the cell the gene product is active
  • nucleus
  • cytoplasm
  • nuclear speck
  • mitochondrion
  • cytosol
  • plasma membrane
  • nucleoplasm

MOLECULAR FUNCTION

What the gene product does at the molecular level
  • ATP binding
  • protein binding
  • protein serine/threonine/tyrosine kinase activity
  • JUN kinase activity
  • protein serine/threonine kinase activity

Gene-Specific Assays for Results You Can Trust

Streamline your workflow with assays designed for this gene. Our targeted dPCR and qPCR assays help you generate meaningful data – efficiently and accurately.