ARFIP2 Gene Summary [Human]
Enables several functions, including GTP-dependent protein binding activity; membrane curvature sensor activity; and phosphatidylinositol-4-phosphate binding activity. Involved in actin cytoskeleton organization. Located in cell cortex; ruffle; and trans-Golgi network membrane. [provided by Alliance of Genome Resources, Apr 2022]
Details
| Type | Protein Coding |
| Official Symbol | ARFIP2 |
| Official Name | ADP ribosylation factor interacting protein 2 [Source:HGNC Symbol;Acc:HGNC:17160] |
| Ensembl ID | ENSG00000132254 |
| Bio databases IDs | |
| Aliases | ADP ribosylation factor interacting protein 2, arfaptin 2 |
| Synonyms | 2310002N04Rik, ARF interacting protein 2, Partner of RAC1, POR, POR1 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human ARFIP2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- GTP binding
- GTP-dependent protein binding
- Arfaptin-like domain
- enzyme binding
- protein binding
- Bin/Amphiphysin/Rvs domain
- identical protein binding
- phosphatidylinositol binding
- phosphorylation site
Pathways
Biological processes and signaling networks where the ARFIP2 gene in human plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- albuminuria
role in cell
- assembly
- formation
- cell death
- abnormal morphology
- organization
- quantity
- remodeling
- entrance
- reorganization
- mitochondrial respiration in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- ruffle
- perinuclear region
- pericentriolar regions
- cell cortex
- Nucleus
- Plasma Membrane
- Golgi Apparatus
- cytosol
- membrane ruffles
- trans Golgi network
- nucleoli
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human ARFIP2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- protein localization to pre-autophagosomal structure
- small GTPase mediated signal transduction
- ruffle organization
- lamellipodium assembly
- intracellular protein transport
- macromitophagy
- actin cytoskeleton organization
- regulation of Arp2/3 complex-mediated actin nucleation
Cellular Component
Where in the cell the gene product is active
- cytoplasm
- cell cortex
- ruffle
- cytosol
- Golgi apparatus
- nucleolus
- trans-Golgi network membrane
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- GTP binding
- phosphatidylinositol-4-phosphate binding
- identical protein binding
- protein domain specific binding
- protein binding
- cadherin binding
- small GTPase binding
- phospholipid binding
- GTP-dependent protein binding