AGTRAP Gene Summary
This gene encodes a transmembrane protein localized to the plasma membrane and perinuclear vesicular structures. The gene product interacts with the angiotensin II type I receptor and negatively regulates angiotensin II signaling. Alternative splicing of this gene generates multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]
Details
| Type | Protein Coding |
| Official Symbol | AGTRAP |
| Official Name | angiotensin II receptor associated protein [Source:HGNC Symbol;Acc:HGNC:13539] |
| Ensembl ID | ENSG00000177674 |
| Bio databases IDs | |
| Aliases | angiotensin II receptor associated protein |
| Synonyms | 3300002E14RIK,angiotensin II receptor-associated protein,angiotensin II, type I receptor-associated protein,AT1R,ATRAP,D4Wsu124e |
| Species | Human, Homo sapiens |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- G-protein coupled receptor
- angiotensin type II receptor
- Angiotensin II, type I receptor-associated protein (AGTRAP)
- protein binding
- identical protein binding
Pathways
Biological processes and signaling networks where the AGTRAP gene plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- fibrosis
- insulin resistance
- atrial fibrillation
- organismal death
- hypertension
- breast cancer
- wasting
- hyperalbuminemia
- septic shock
- laser induced choroidal neovascularization
role in cell
- expression in
- production in
- cell viability
- activation in
- proliferation
- migration
- stabilization in
- quantity
- phosphorylation in
- consumption in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- intracellular membrane-bounded organelle
- Cytoplasm
- cell surface
- intracellular space
- cellular membrane
- cell cortex
- endosomes
- vesicles
- Golgi Apparatus
- Endoplasmic Reticulum
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the AGTRAP gene, providing context for its role in the cell.
biological PROCESS
Functions and activities the gene product is involved in
- response to hypoxia
- angiotensin-mediated signaling pathway
- regulation of blood pressure
cellular COMPONENT
Where in the cell the gene product is active
- endoplasmic reticulum membrane
- cytoplasmic vesicle membrane
- intracellular membrane-bounded organelle
- cell cortex
- Golgi apparatus
- Golgi membrane
- plasma membrane
molecular FUNCTION
What the gene product does at the molecular level
- protein binding
- angiotensin type II receptor activity