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This gene encodes a transmembrane protein localized to the plasma membrane and perinuclear vesicular structures. The gene product interacts with the angiotensin II type I receptor and negatively regulates angiotensin II signaling. Alternative splicing of this gene generates multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]
Details
Type
Protein Coding
Official Symbol
AGTRAP
Official Name
angiotensin II receptor associated protein [Source:HGNC Symbol;Acc:HGNC:13539]
3300002E14RIK,angiotensin II receptor-associated protein,angiotensin II, type I receptor-associated protein,AT1R,ATRAP,D4Wsu124e
Species
Human, Homo sapiens
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
G-protein coupled receptor
angiotensin type II receptor
Angiotensin II, type I receptor-associated protein (AGTRAP)
protein binding
identical protein binding
Pathways
Biological processes and signaling networks where the AGTRAP gene plays a role, providing insight into its function and relevance in health or disease.
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
Plasma Membrane
intracellular membrane-bounded organelle
Cytoplasm
cell surface
intracellular space
cellular membrane
cell cortex
endosomes
vesicles
Golgi Apparatus
Endoplasmic Reticulum
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the AGTRAP gene, providing context for its role in the cell.
biological PROCESS
Functions and activities the gene product is involved in
response to hypoxia
angiotensin-mediated signaling pathway
regulation of blood pressure
cellular COMPONENT
Where in the cell the gene product is active
endoplasmic reticulum membrane
cytoplasmic vesicle membrane
intracellular membrane-bounded organelle
cell cortex
Golgi apparatus
Golgi membrane
plasma membrane
molecular FUNCTION
What the gene product does at the molecular level
protein binding
angiotensin type II receptor activity
Gene-Specific Assays for Results You Can Trust
Streamline your workflow with assays designed for this gene. Our targeted dPCR and qPCR assays help you generate meaningful data – efficiently and accurately.