RNF130 Gene Summary [Human]
The protein encoded by this gene contains a RING finger motif and is similar to g1, a Drosophila zinc-finger protein that is expressed in mesoderm and involved in embryonic development. The expression of the mouse counterpart was found to be upregulated in myeloblastic cells following IL3 deprivation, suggesting that this gene may regulate growth factor withdrawal-induced apoptosis of myeloid precursor cells. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013]
Details
| Type | Protein Coding |
| Official Symbol | RNF130 |
| Official Name | ring finger protein 130 [Source:HGNC Symbol;Acc:HGNC:18280] |
| Ensembl ID | ENSG00000113269 |
| Bio databases IDs | |
| Aliases | ring finger protein 130 |
| Synonyms | 2510042A13Rik, G1RP, G1RZFP, GOLIATH, GP, LOC552912, ring finger protein 130 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human RNF130 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- RING-type zinc-finger
- PA
- RING finger (Really Interesting New Gene) domain and U-box domain superfamily
- Ring finger
- peptidase
- ubiquitin-protein transferase activity
- Ring finger domain
- RING-like zinc finger
- RING-H2 zinc finger domain
- Zinc finger, C3HC4 type (RING finger)
- zinc-RING finger domain
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- osteoarthritis
- Alzheimer disease
- microgliosis
- diabetes mellitus
- memory deficits
- glioma formation
- pilocytic astrocytoma
regulates
- MAPT
- calcineurin (family)
role in cell
- activation
- apoptosis
- glycolysis in
- deubiquitination in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- cellular membrane
- flagella
- Mitochondria
- mitochondrial inner membrane
- residual bodies
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human RNF130 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- apoptotic process
- programmed cell death
- protein ubiquitination
- ubiquitin-dependent protein catabolic process
Cellular Component
Where in the cell the gene product is active
- cytoplasm
- membrane
Molecular Function
What the gene product does at the molecular level
- ubiquitin-protein ligase activity
- metal ion binding