BET1 Gene Summary [Human]

This gene encodes a golgi-associated membrane protein that participates in vesicular transport from the endoplasmic reticulum (ER) to the Golgi complex. The encoded protein functions as a soluble N-ethylaleimide-sensitive factor attachment protein receptor and may be involved in the docking of ER-derived vesicles with the cis-Golgi membrane. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2015]

Details

Type
Nonsense Mediated Decay
Official Symbol
BET1
Official Name
Bet1 golgi vesicular membrane trafficking protein [Source:HGNC Symbol;Acc:HGNC:14562]
Ensembl ID
ENSG00000105829
Bio databases IDs NCBI: 10282 Ensembl: ENSG00000105829
Aliases Bet1 golgi vesicular membrane trafficking protein, Golgi vesicular membrane trafficking protein p18, Bet1p homolog
Synonyms Bet1 golgi vesicular membrane trafficking protein, Golgi vesicular membrane trafficking protein p18, HBET1, MDRP
Species
Human, Homo sapiens
OrthologiesMouseRat

Protein Domains

A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human BET1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
  • cytoplasmic domain
  • Helical region found in SNAREs
  • protein binding
  • SNARE motif
  • transporter
  • syntaxin binding

Top Findings

The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
  • COVID-19
regulated by
role in cell
  • binding in

Subcellular Expression

Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
  • Cytoplasm
  • endoplasmic reticulum fraction
  • Golgi-enriched fraction
  • membrane fraction
  • Golgi-intermediate compartment membrane fractions
  • perinuclear Golgi regions
  • cellular membrane
  • Golgi Apparatus
  • Endoplasmic Reticulum
  • ER-to-Golgi intermediate compartment
  • cytosol
  • endoplasmic reticulum buds
  • cis face of the Golgi apparatus
  • Golgi membrane
  • Golgi buds
  • cis Golgi networks
  • late endosomes
  • peri-Golgi vesicles
  • transport vesicles
  • microsomal membrane
  • Golgi cisternae

Gene Ontology Annotations

Describes the biological processes, cellular components, and molecular functions associated with the human BET1 gene, providing context for its role in the cell.

Biological Process

Functions and activities the gene product is involved in
  • ER to Golgi vesicle-mediated transport
  • protein transport
  • vesicle fusion with Golgi apparatus

Cellular Component

Where in the cell the gene product is active
  • endoplasmic reticulum membrane
  • membrane
  • SNARE complex
  • Golgi membrane
  • transport vesicle
  • endoplasmic reticulum-Golgi intermediate compartment membrane

Molecular Function

What the gene product does at the molecular level
  • protein binding
  • SNAP receptor activity

Gene-Specific Assays for Results You Can Trust

Streamline your workflow with assays designed for this gene. Our targeted dPCR and qPCR assays help you generate meaningful data – efficiently and accurately.