CEBPZ Gene Summary [Human]
This gene belongs to the CBF/Mak21 family. The encoded protein plays a role in cellular response to environmental stimuli through a transcriptional process that involves heat shock factors, conserved DNA elements (heat shock elements or HSEs) and CCAAT boxes. The protein acts as a DNA-binding transcriptional activator and regulates the heat-shock protein 70 (HSP70) promoter in a CCAAT-dependent manner. The protein is also involved in cell growth and differentiation, particularly, hematopoietic differentiation. [provided by RefSeq, Nov 2020]
Details
| Type | Protein Coding |
| Official Symbol | CEBPZ |
| Official Name | CCAAT enhancer binding protein zeta [Source:HGNC Symbol;Acc:HGNC:24218] |
| Ensembl ID | ENSG00000115816 |
| Bio databases IDs | |
| Aliases | CCAAT enhancer binding protein zeta |
| Synonyms | CBF, CBF2, Cbf/hsp70, CCAAT-binding factor, CCAAT enhancer binding protein zeta, CCAAT/enhancer binding protein zeta, CCAAT enhancer binding protein ζ, CCAAT/enhancer binding protein ζ, CEBPA-RS1, C/EBP ZETA, C/EBP ζ, HSP-CBF, NOC1 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human CEBPZ often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- transcription regulator
- transcription co-activator
- protein binding
- glutamine-rich domain
- CBF/Mak21 family
Pathways
Biological processes and signaling networks where the CEBPZ gene in human plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- de novo acute myeloid leukemia
role in cell
- expression in
- structural integrity
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- intracellular membrane-bounded organelle
- nucleoplasm
- nucleoli
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human CEBPZ gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- positive regulation of transcription from RNA polymerase II promoter
Cellular Component
Where in the cell the gene product is active
- nucleus
- CCAAT-binding factor complex
Molecular Function
What the gene product does at the molecular level
- DNA binding
- RNA binding
- transcription coactivator activity