FCGR2A Gene Summary [Human]
This gene encodes one member of a family of immunoglobulin Fc receptor genes found on the surface of many immune response cells. The protein encoded by this gene is a cell surface receptor found on phagocytic cells such as macrophages and neutrophils, and is involved in the process of phagocytosis and clearing of immune complexes. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2008]
Details
| Type | Protein Coding |
| Official Symbol | FCGR2A |
| Official Name | Fc fragment of IgG receptor IIa [Source:HGNC Symbol;Acc:HGNC:3616] |
| Ensembl ID | ENSG00000143226 |
| Bio databases IDs | |
| Aliases | Fc fragment of IgG receptor IIa, Fc gamma receptor IIa, Immunoglobulin G Fc receptor II |
| Synonyms | CD32, CD32A, CDw32, FCG2, FC gamma receptor 2A, Fc gamma receptor IIa, FC gamma RIIA, FcGR, FCGR2, FCGR2A1, FcRII-a, Fc γ R2a, Fc γ receptor 2, FC γ receptor 2A, Fc γ receptor IIa, FC γ RIIA, IGFR2, IgG Fc receptor II-a |
| Species | Human, Homo sapiens |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human FCGR2A often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- extracellular domain
- cytoplasmic domain
- immunoglobulin domain
- transmembrane domain
- Immunoglobulin like
- intracellular domain
- Immunoglobulin I-set domain
- protein binding
- T-cell surface glycoprotein CD3 delta chain
Pathways
Biological processes and signaling networks where the FCGR2A gene in human plays a role, providing insight into its function and relevance in health or disease.
- B Cell Receptor Signaling
- Dendritic Cell Maturation
- Fcγ Receptor-mediated Phagocytosis in Macrophages and Monocytes
- IL-10 Signaling
- IL-12 Signaling and Production in Macrophages
- Natural Killer Cell Signaling
- Parkinson's Signaling Pathway
- Phagosome Formation
- Role of NFAT in Regulation of the Immune Response
- Systemic Lupus Erythematosus Signaling
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- HIV infection
- leukemia
- irritable bowel syndrome
- cancer
- Guillain-Barré syndrome
- inflammatory bowel disease
- chronic inflammatory demyelinating polyradiculoneuropathy
- Unverricht-Lundborg syndrome
- immunodeficiency
- rheumatoid arthritis
role in cell
- production in
- proliferation
- activation in
- quantity
- expression in
- phosphorylation in
- accumulation in
- phagocytosis by
- shape change
- binding
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- raft fractions
- cell surface
- membrane surface
- cellular membrane
- secretory granule membrane
- microvilli
- perikaryon
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human FCGR2A gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- antibody-dependent cellular cytotoxicity
- Fc-gamma receptor signaling pathway
- cell surface receptor signaling pathway
- positive regulation of tumor necrosis factor production
- positive regulation of phagocytosis
Cellular Component
Where in the cell the gene product is active
- secretory granule membrane
- external side of plasma membrane
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- protein binding
- IgG receptor activity
- IgG binding