DPH2 Gene Summary [Human]
This gene is one of two human genes similar to the yeast gene dph2. The yeast gene was identified by its ability to complement a diphthamide mutant strain, and thus probably functions in diphthamide biosynthesis. Diphthamide is a post-translationally modified histidine residue present in elongation factor 2 (EF2) that is the target of diphtheria toxin ADP-ribosylation. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2016]
Details
| Type | Processed Transcript |
| Official Symbol | DPH2 |
| Official Name | diphthamide biosynthesis 2 [Source:HGNC Symbol;Acc:HGNC:3004] |
| Ensembl ID | ENSG00000132768 |
| Bio databases IDs | |
| Aliases | diphthamide biosynthesis 2, 2-(3-amino-3-carboxypropyl)histidine synthase subunit 2 |
| Synonyms | 9130020C19Rik, DEDSSH2, diphthamide biosynthesis 2, DPH2 homolog, DPH2L2 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human DPH2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- binding protein
- Putative diphthamide synthesis protein
- enzyme
- protein binding
- diphthamide biosynthesis protein 2
- diphthamide biosynthesis enzyme Dph1/Dph2 domain
- Non-methyl alkyl or aryl group transferase
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- cytosol
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human DPH2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- peptidyl-diphthamide biosynthetic process from peptidyl-histidine
Cellular Component
Where in the cell the gene product is active
- cytosol
- macromolecular complex
Molecular Function
What the gene product does at the molecular level
- protein binding
- metal ion binding
- 4 iron, 4 sulfur cluster binding