Dph2 Gene Summary [Mouse]
Predicted to enable 4 iron, 4 sulfur cluster binding activity. Predicted to contribute to 2-(3-amino-3-carboxypropyl)histidine synthase activity. Predicted to be involved in protein histidyl modification to diphthamide. Part of 2-(3-amino-3-carboxypropyl)histidine synthase complex. Is expressed in liver lobe. Human ortholog(s) of this gene implicated in diphthamide deficiency syndrome 2. Orthologous to human DPH2 (diphthamide biosynthesis 2). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Dph2 |
| Official Name | DPH2 homolog [Source:MGI Symbol;Acc:MGI:1914978] |
| Ensembl ID | ENSMUSG00000028540 |
| Bio databases IDs | |
| Aliases | DPH2 homolog |
| Synonyms | 9130020C19Rik, DEDSSH2, diphthamide biosynthesis 2, DPH2 homolog, DPH2L2 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Dph2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- binding protein
- Putative diphthamide synthesis protein
- enzyme
- protein binding
- diphthamide biosynthesis protein 2
- diphthamide biosynthesis enzyme Dph1/Dph2 domain
- Non-methyl alkyl or aryl group transferase
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- cytosol
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Dph2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- peptidyl-diphthamide biosynthetic process from peptidyl-histidine
Cellular Component
Where in the cell the gene product is active
- cytosol
- macromolecular complex
Molecular Function
What the gene product does at the molecular level
- protein binding
- metal ion binding
- 4 iron, 4 sulfur cluster binding