TPTE2 Gene Summary [Human]
TPIP is a member of a large class of membrane-associated phosphatases with substrate specificity for the 3-position phosphate of inositol phospholipids.[supplied by OMIM, Jul 2002]
Details
| Type | Protein Coding |
| Official Symbol | TPTE2 |
| Official Name | transmembrane phosphoinositide 3-phosphatase and tensin homolog 2 [Source:HGNC Symbol;Acc:HGNC:17299] |
| Ensembl ID | ENSG00000132958 |
| Bio databases IDs | |
| Aliases | transmembrane phosphoinositide 3-phosphatase and tensin homolog 2 |
| Synonyms | TPIP, transmembrane phosphoinositide 3-phosphatase and tensin homolog 2 |
| Species | Human, Homo sapiens |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human TPTE2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- C2 domain of PTEN tumour-suppressor protein
- phosphatase
- PTP_DSP_cys
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Plasma Membrane
- endoplasmic reticulum membrane
- Golgi membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human TPTE2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- ion transmembrane transport
- phosphatidylinositol biosynthetic process
- dephosphorylation
Cellular Component
Where in the cell the gene product is active
- endoplasmic reticulum membrane
- cytosol
- Golgi membrane
Molecular Function
What the gene product does at the molecular level
- ion channel activity
- protein tyrosine phosphatase activity
- phosphatidylinositol-3,4-bisphosphate 3-phosphatase activity
- phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity