TPTE Gene Summary [Human]
This gene encodes a PTEN-related tyrosine phosphatase which may play a role in the signal transduction pathways of the endocrine or spermatogenic function of the testis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2014]
Details
| Type | Protein Coding |
| Official Symbol | TPTE |
| Official Name | transmembrane phosphatase with tensin homology [Source:HGNC Symbol;Acc:HGNC:12023] |
| Ensembl ID | ENSG00000274391 |
| Bio databases IDs | |
| Aliases | transmembrane phosphatase with tensin homology, PTEN-related tyrosine phosphatase, cancer/testis antigen 44 |
| Synonyms | CT44, PTEN2, TPTE1, transmembrane phosphatase with tensin homology |
| Species | Human, Homo sapiens |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human TPTE often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Protein tyrosine phosphatase, catalytic domain, undefined specificity
- protein-tyrosine-phoshatase
- C2 domain of PTEN tumour-suppressor protein
- phosphatase
- protein binding
- PTP_DSP_cys
- Protein tyrosine phosphatase, catalytic domain motif
- PTPase domain
Pathways
Biological processes and signaling networks where the TPTE gene in human plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- cellular membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human TPTE gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- signal transduction
- ion transmembrane transport
- protein dephosphorylation
- dephosphorylation
Cellular Component
Where in the cell the gene product is active
- membrane
- cytosol
Molecular Function
What the gene product does at the molecular level
- ion channel activity
- protein tyrosine phosphatase activity
- phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity