LGR4 Gene Summary [Human]
The protein encoded by this gene is a G-protein coupled receptor that binds R-spondins and activates the Wnt signaling pathway. This Wnt signaling pathway activation is necessary for proper development of many organs of the body. [provided by RefSeq, Oct 2016]
Details
| Type | Protein Coding |
| Official Symbol | LGR4 |
| Official Name | leucine rich repeat containing G protein-coupled receptor 4 [Source:HGNC Symbol;Acc:HGNC:13299] |
| Ensembl ID | ENSG00000205213 |
| Bio databases IDs | |
| Aliases | leucine rich repeat containing G protein-coupled receptor 4 |
| Synonyms | 9130225G07, A330106J01RIK, A930009A08Rik, BNMD17, DPSL, GPCR48, GPR48, leucine-rich repeat-containing G protein-coupled receptor 4 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human LGR4 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Leucine-rich repeats, outliers
- G-protein coupled receptor
- extracellular domain
- Leucine-rich repeats, typical (most populated) subfamily
- protein phosphatase 1 regulatory subunit 42
- ectodomain
- Leucine rich repeat
- BspA type Leucine rich repeat region (6 copies)
- protein binding
- Leucine Rich repeats (2 copies)
- seven-transmembrane G protein-coupled receptor superfamily
- leucine-rich repeat
- 7 transmembrane receptor (rhodopsin family)
- Leucine rich repeat N-terminal domain
- transmembrane receptor
Pathways
Biological processes and signaling networks where the LGR4 gene in human plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- colon carcinoma
- osteoporosis
- prostate cancer
- adenomyosis
- metastasis
- hypoplasia
- growth failure
- lung adenocarcinoma
- lung adenocarcinoma formation
role in cell
- invasion by
- degradation in
- expression in
- proliferation
- migration
- phosphorylation in
- apoptosis
- binding in
- quantity
- ubiquitination in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- cell surface
- cellular membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human LGR4 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- bone remodeling
- bone mineralization
- negative regulation of toll-like receptor signaling pathway
- spermatogenesis
- positive regulation of canonical Wnt receptor signaling pathway
- adenylate cyclase-activating G-protein coupled receptor signaling pathway
- metanephric nephron tubule morphogenesis
- positive regulation of branching involved in ureteric bud morphogenesis
- circadian regulation of gene expression
- metanephric glomerulus development
- hair follicle development
- male genitalia development
- digestive tract development
- innate immune response
- osteoblast differentiation
- Wnt receptor signaling pathway
- negative regulation of cytokine production
- epithelial cell proliferation involved in renal tubule morphogenesis
- activation of adenylate cyclase activity
Cellular Component
Where in the cell the gene product is active
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- G-protein coupled receptor activity
- G-protein coupled peptide receptor activity
- protein binding
- transmembrane signaling receptor activity
- protein-hormone receptor activity