MED4 Gene Summary [Human]
This gene encodes a component of the Mediator complex. The Mediator complex interacts with DNA-binding gene-specific transcription factors to modulate transcription by RNA polymerase II. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Jul 2012]
Details
| Type | Non-Stop Decay |
| Official Symbol | MED4 |
| Official Name | mediator complex subunit 4 [Source:HGNC Symbol;Acc:HGNC:17903] |
| Ensembl ID | ENSG00000136146 |
| Bio databases IDs | |
| Aliases | mediator complex subunit 4 |
| Synonyms | 2410046H15Rik, ARC36, D receptor interacting, DRIP36, HSPC126, MED36, mediator complex subunit 4, TRAP36, Vdirp, VDRIP |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human MED4 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- transcription regulator
- transcription co-activator
- transcription cofactor
- protein binding
- thyroid hormone receptor binding
Pathways
Biological processes and signaling networks where the MED4 gene in human plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- nuclear fraction
- nucleoplasm
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human MED4 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- positive regulation of transcription elongation from RNA polymerase II promoter
- RNA polymerase II transcriptional preinitiation complex assembly
- positive regulation of transcription initiation from RNA polymerase II promoter
- positive regulation of transcription, DNA-dependent
- transcription from RNA polymerase II promoter
- regulation of transcription from RNA polymerase II promoter
Cellular Component
Where in the cell the gene product is active
- nucleus
- core mediator complex
- membrane
- mediator complex
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- protein binding
- transcription cofactor activity
- transcription coactivator activity
- ligand-dependent nuclear receptor transcription coactivator activity
- vitamin D receptor binding
- thyroid hormone receptor binding