ALOX5AP Gene Summary [Human]
This gene encodes a protein which, with 5-lipoxygenase, is required for leukotriene synthesis. Leukotrienes are arachidonic acid metabolites which have been implicated in various types of inflammatory responses, including asthma, arthritis and psoriasis. This protein localizes to the plasma membrane. Inhibitors of its function impede translocation of 5-lipoxygenase from the cytoplasm to the cell membrane and inhibit 5-lipoxygenase activation. Alternatively spliced transcript variants encoding different isoforms have been identified for this gene. [provided by RefSeq, Feb 2011]
Details
| Type | Protein Coding |
| Official Symbol | ALOX5AP |
| Official Name | arachidonate 5-lipoxygenase activating protein [Source:HGNC Symbol;Acc:HGNC:436] |
| Ensembl ID | ENSG00000132965 |
| Bio databases IDs | |
| Aliases | arachidonate 5-lipoxygenase activating protein, five-lipoxygenase activating protein, MK-886-binding protein |
| Synonyms | Arachidonate 5-lipoxygenase activating, arachidonate 5-lipoxygenase activating protein, FLAP |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human ALOX5AP often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- arachidonate 5-lipoxygenase
- binding protein
- MAPEG family
- enzyme binding
- arachidonic acid binding
- enzyme
- protein binding
- identical protein binding
Pathways
Biological processes and signaling networks where the ALOX5AP gene in human plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- X-linked immunodeficiency with magnesium defect, Epstein-Barr virus infection and neoplasia
- abdominal aortic aneurysm
- arthritis
- bipolar I disorder
- hypersensitivity reaction type I
- COVID-19
- coronary artery disease
- ulcerative colitis
- acute inflammation
- insulin-dependent diabetes mellitus
role in cell
- proliferation
- formation in
- migration
- cellular infiltration by
- recruitment
- response by
- generation in
- biosynthesis in
- conversion in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- cellular membrane
- Nucleus
- Endoplasmic Reticulum
- nuclear envelope
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human ALOX5AP gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- positive regulation of acute inflammatory response
- leukotriene biosynthetic process
- cellular response to calcium ion
- lipoxygenase pathway
- protein homotrimerization
- leukotriene production involved in inflammatory response
Cellular Component
Where in the cell the gene product is active
- endoplasmic reticulum membrane
- nuclear envelope
- nuclear membrane
- membrane
- endoplasmic reticulum
Molecular Function
What the gene product does at the molecular level
- identical protein binding
- protein binding
- glutathione peroxidase activity
- arachidonate 5-lipoxygenase activity
- enzyme activator activity
- glutathione transferase activity
- leukotriene-C4 synthase activity
- arachidonic acid binding
- enzyme binding