CEBPD Gene Summary [Human]
The protein encoded by this intronless gene is a bZIP transcription factor which can bind as a homodimer to certain DNA regulatory regions. It can also form heterodimers with the related protein CEBP-alpha. The encoded protein is important in the regulation of genes involved in immune and inflammatory responses, and may be involved in the regulation of genes associated with activation and/or differentiation of macrophages. The cytogenetic location of this locus has been reported as both 8p11 and 8q11. [provided by RefSeq, Sep 2010]
Details
| Type | Protein Coding |
| Official Symbol | CEBPD |
| Official Name | CCAAT enhancer binding protein delta [Source:HGNC Symbol;Acc:HGNC:1835] |
| Ensembl ID | ENSG00000221869 |
| Bio databases IDs | |
| Aliases | CCAAT enhancer binding protein delta |
| Synonyms | CCAAT enhancer binding protein delta, CCAAT/enhancer binding protein delta, CCAAT enhancer binding protein δ, CCAAT/enhancer-binding protein-δ, C/EBPd, C/EBP-delta, C/EBP-δ, Cebp δ, CELF, C/EPB δ, CRP3, NF-IL6-beta, NF-IL6-β |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human CEBPD often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- RNA polymerase II transcription regulatory region sequence-specific binding transcriptional activator activity
- transcription regulator
- dimerization domain
- DNA binding domain
- nucleic acid binding
- transcription activation domain
- Basic region leucine zipper
- leucine zipper domain
- protein binding
- sequence-specific DNA binding
- identical protein binding
- DNA binding
- bZIP domain
- RNA polymerase II transcription factor activity, sequence-specific DNA binding
- double-stranded DNA binding
- bZIP
- basic region leucin zipper
Pathways
Biological processes and signaling networks where the CEBPD gene in human plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- metastasis
- breast cancer
- neoplasia
- primary myelofibrosis
- plasma cell neoplasm
- Alzheimer disease
- tumorigenesis
- X-linked immunodeficiency with magnesium defect, Epstein-Barr virus infection and neoplasia
- psoriasis
- organismal death
role in cell
- apoptosis
- cell viability
- production in
- expression in
- activation in
- phosphorylation in
- proliferation
- invasion
- induction in
- acidification in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- nuclear fraction
- Cytoplasm
- nuclear foci
- nucleoplasm
- chromatin
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human CEBPD gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- inner ear development
- negative regulation of transcription, DNA-dependent
- regulation of cell differentiation
- transcription from RNA polymerase II promoter
- fat cell differentiation
- positive regulation of transcription from RNA polymerase II promoter
- positive regulation of osteoblast differentiation
- hemopoietic progenitor cell differentiation
- regulation of transcription from RNA polymerase II promoter
Cellular Component
Where in the cell the gene product is active
- nucleus
- chromatin
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- identical protein binding
- protein binding
- RNA polymerase II core promoter proximal region sequence-specific DNA binding
- RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
- sequence-specific DNA binding RNA polymerase II transcription factor activity