LYVE1
LYVE1 Gene Summary
This gene encodes a type I integral membrane glycoprotein. The encoded protein acts as a receptor and binds to both soluble and immobilized hyaluronan. This protein may function in lymphatic hyaluronan transport and have a role in tumor metastasis. [provided by RefSeq, Jul 2008]
Details
| Type | Protein Coding |
| Official Symbol | LYVE1 |
| Official Name | lymphatic vessel endothelial hyaluronan receptor 1 [Source:HGNC Symbol;Acc:HGNC:14687] |
| Ensembl ID | ENSG00000133800 |
| Bio databases IDs | |
| Aliases | lymphatic vessel endothelial hyaluronan receptor 1 |
| Synonyms | 1200012G08Rik,CRSBP-1,HAR,lymphatic vessel endothelial hyaluronan receptor 1,XLKD1 |
| Species | Human, Homo sapiens |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- extracellular domain
- cargo receptor activity
- signaling receptor activity
- Link_Domain
- protein binding
- Extracellular link domain
- hyaluronic acid binding
- transmembrane receptor
Pathways
Biological processes and signaling networks where the LYVE1 gene plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
binds
- CYSRT1
- PDGFB
- EMP3
- hyaluronic acid
- KRT34
- KRTAP10-3
- NBPF19
- NINJ2
- NOTCH2NLA/NOTCH2NLB
- KRTAP6-2
disease
- hepatocellular carcinoma
- liver cancer
- epithelial cancer
- uterine leiomyoma
- leiomyomatosis
- heart failure
- androgenic alopecia
- atrial fibrillation
- ulcerative colitis
- non-small cell lung carcinoma
regulated by
- lipopolysaccharide
- dexamethasone
- tetradecanoylphorbol acetate
- SPARC
- TNF
- methylprednisolone
- PRL
- FGF2
- TGFB1
- Immunoglobulin
regulates
- FGF2
- hyaluronic acid
- glycosaminoglycan
role in cell
- proliferation
- migration
- invasion by
- extravasation
- function in
- adhesion
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- cell surface
- cell periphery
- perinuclear region
- cellular membrane
- apical membrane
- basolateral membrane
- cytoplasmic vesicles
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the LYVE1 gene, providing context for its role in the cell.
BIOLOGICAL PROCESS
Functions and activities the gene product is involved in
- cell-matrix adhesion
- response to wounding
- anatomical structure morphogenesis
- positive regulation of cellular extravasation
- receptor-mediated endocytosis
- hyaluronan catabolic process
CELLULAR COMPONENT
Where in the cell the gene product is active
- extracellular vesicular exosome
- membrane
- plasma membrane
MOLECULAR FUNCTION
What the gene product does at the molecular level
- protein binding
- transmembrane signaling receptor activity
- cargo receptor activity
- signaling receptor activity
- hyaluronic acid binding