SPARC Gene Summary [Human]
This gene encodes a cysteine-rich acidic matrix-associated protein. The encoded protein is required for the collagen in bone to become calcified but is also involved in extracellular matrix synthesis and promotion of changes to cell shape. The gene product has been associated with tumor suppression but has also been correlated with metastasis based on changes to cell shape which can promote tumor cell invasion. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jun 2015]
Details
| Type | Protein Coding |
| Official Symbol | SPARC |
| Official Name | secreted protein acidic and cysteine rich [Source:HGNC Symbol;Acc:HGNC:11219] |
| Ensembl ID | ENSG00000113140 |
| Bio databases IDs | |
| Aliases | secreted protein acidic and cysteine rich, cysteine-rich protein, secreted protein acidic and rich in cysteine |
| Synonyms | Basement membrane protein-40, BM-40, OI17, ON, ONT, secreted acidic cysteine rich glycoprotein, secreted protein acidic and cysteine rich |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human SPARC often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- EF-Hand
- extracellular domain
- extracellular matrix binding
- signal peptide
- calcium ion binding
- protein binding
- KAZAL_FS
- acidic domain
- Follistatin/Osteonectin-like EGF domain
- EFh_SPARC_EC
- collagen binding
- Secreted protein acidic and rich in cysteine Ca binding region
- follistatin (FS) domain
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- epithelial cancer
- neoplasia
- Alzheimer disease
- anaplastic thyroid carcinoma
- anaplastic thyroid cancer
- epithelial thyroid cancer
- microgliosis
- metastasis
- peripheral T-cell lymphoma
- T-cell non-Hodgkin disease
role in cell
- expression in
- formation
- accumulation in
- quantity
- proliferation
- apoptosis
- activation in
- production in
- survival
- damage
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Extracellular Space
- membrane fraction
- glutaminergic synapse
- intracellular membrane-bounded organelle
- Cytoplasm
- cell surface
- organelle lumens
- Plasma Membrane
- vesicles
- cytoplasmic particles
- nuclear matrix
- alpha granules
- synapse
- extracellular matrix
- membrane processes
- plasma
- basement membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human SPARC gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of angiogenesis
- regulation of cell morphogenesis
- anatomical structure development
- negative regulation of endothelial cell proliferation
- positive regulation of endothelial cell migration
Cellular Component
Where in the cell the gene product is active
- platelet alpha granule lumen
- platelet alpha granule
- platelet alpha granule membrane
- extracellular region
- plasma membrane
- cell surface
- extracellular space
- basement membrane
- cytoplasm
- endocytic vesicle lumen
- intracellular membrane-bounded organelle
- mitochondrion
- nuclear matrix
Molecular Function
What the gene product does at the molecular level
- extracellular matrix binding
- protein binding
- collagen binding
- calcium ion binding
- extracellular matrix structural constituent