MICAL2 Gene Summary [Human]
The protein encoded by this gene is a monooxygenase that enhances depolymerization of F-actin and is therefore involved in cytoskeletal dynamics. The encoded protein is a regulator of the SRF signaling pathway. Increased expression of this gene has been associated with cancer progression and metastasis. [provided by RefSeq, Oct 2016]
Details
| Type | Protein Coding |
| Official Symbol | MICAL2 |
| Official Name | microtubule associated monooxygenase, calponin and LIM domain containing 2 [Source:HGNC Symbol;Acc:HGNC:24693] |
| Ensembl ID | ENSG00000133816 |
| Bio databases IDs | |
| Aliases | microtubule associated monooxygenase, calponin and LIM domain containing 2 |
| Synonyms | 4921517J23Rik, 5330438E18RIK, 9530064J02, Ebitein1, KIAA0750, MICAL2PV1, MICAL2PV2, MICALCL, microtubule associated monooxygenase, calponin and LIM domain containing 2, mKIAA0750, RGD1311773, RSB-11-77 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human MICAL2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Domain of unknown function (DUF4515)
- protein kinase binding
- Calponin homology domain
- Ezrin/radixin/moesin, alpha-helical domain
- LIM is a small protein-protein interaction domain, containing two zinc fingers
- oxidoreductase
- Phosphatidylinositol 3-kinase regulatory subunit P85 inter-SH2 domain
- FinO_conjug_rep
- enzyme
- protein binding
- FAD binding
- actin binding
- ClassIIa_HDAC_Gln-rich-N
- Bivalent Mical/EHBP Rab binding domain
- NAD(P)-binding Rossmann-like domain
- NADPH oxidase
- calponin homology (CH) domain superfamily
- monooxygenase
- Programmed cell death protein 7
- NADH2 or NADPH2 1 atom incorporation:oxygen oxidoreductase
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- renal cell carcinoma
- renal cell cancer
- COVID-19
- organismal death
- major depression
- Dupuytren contracture
- prostate cancer
- Alzheimer disease
- neuroticism
- vitiligo
regulates
- DNA promoter
- DNA endogenous promoter
- actin
- F Actin
- RNA polymerase II
role in cell
- cell viability
- cell death
- proliferation
- migration
- invasiveness
- formation
- depolymerization
- formation in
- organization
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Nucleus
- actin filaments
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human MICAL2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- heart development
- sulfur oxidation
- cytoskeleton organization
- actin filament depolymerization
- heart looping
- positive regulation of transcription from RNA polymerase II promoter
Cellular Component
Where in the cell the gene product is active
- nucleus
- cytoplasm
- actin filament
Molecular Function
What the gene product does at the molecular level
- FAD binding
- protein binding
- actin binding
- metal ion binding
- oxidoreductase activity
- NAD(P)H oxidase activity
- oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NADH or NADPH as one donor, and incorporation of one atom of oxygen
- mitogen-activated protein kinase binding
- monooxygenase activity