FLT1 Gene Summary [Human]
This gene encodes a member of the vascular endothelial growth factor receptor (VEGFR) family. VEGFR family members are receptor tyrosine kinases (RTKs) which contain an extracellular ligand-binding region with seven immunoglobulin (Ig)-like domains, a transmembrane segment, and a tyrosine kinase (TK) domain within the cytoplasmic domain. This protein binds to VEGFR-A, VEGFR-B and placental growth factor and plays an important role in angiogenesis and vasculogenesis. Expression of this receptor is found in vascular endothelial cells, placental trophoblast cells and peripheral blood monocytes. Multiple transcript variants encoding different isoforms have been found for this gene. Isoforms include a full-length transmembrane receptor isoform and shortened, soluble isoforms. The soluble isoforms are associated with the onset of pre-eclampsia.[provided by RefSeq, May 2009]
Details
| Type | Protein Coding |
| Official Symbol | FLT1 |
| Official Name | fms related receptor tyrosine kinase 1 [Source:HGNC Symbol;Acc:HGNC:3763] |
| Ensembl ID | ENSG00000102755 |
| Bio databases IDs | |
| Aliases | fms related receptor tyrosine kinase 1, vascular endothelial growth factor receptor 1, vascular permeability factor receptor |
| Synonyms | FLT, FMS-like tyrosine kinase 1, Fms related receptor tyrosine kinase 1, LOC100911280, sFlt1, VEGFR-1 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human FLT1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Ig-like domain on T-cell surface glycoprotein CD3 epsilon chain
- ATP binding
- protein-tyrosine kinase
- Protein kinase domain
- identical protein binding
- T-cell surface glycoprotein CD3 delta chain
- cytoplasmic domain
- ligand-binding domain
- Immunoglobulin like
- intracellular domain
- immunoglobulin-like protein domain
- vascular endothelial growth factor receptor
- membrane-proximal domain
- Tyrosine kinase, catalytic domain
- Immunoglobulin V-set domain
- growth factor binding
- transmembrane receptor
- extracellular domain
- activation domain
- Protein kinase (unclassified specificity)
- Immunoglobulin V-Type
- Protein tyrosine and serine/threonine kinase
- immunoglobulin domain
- ectodomain
- Immunoglobulin I-set domain
- protein binding
- kinase
- Serine/Threonine protein kinases, catalytic domain
- Protein Kinases, catalytic domain
- transmembrane receptor protein tyrosine kinase
- transmembrane domain
- tyrosine kinase domain
- protein homodimerization
- hinge domain
Pathways
Biological processes and signaling networks where the FLT1 gene in human plays a role, providing insight into its function and relevance in health or disease.
- CREB Signaling in Neurons
- eNOS Signaling
- FAK Signaling
- Hepatic Fibrosis / Hepatic Stellate Cell Activation
- HIF1α Signaling
- IL-15 Production
- IL-8 Signaling
- NF-κB Signaling
- Nitric Oxide Signaling in the Cardiovascular System
- PTEN Signaling
- Role of Tissue Factor in Cancer
- Sperm Motility
- STAT3 Pathway
- VEGF Family Ligand-Receptor Interactions
- VEGF Signaling
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- metastatic colorectal cancer
- tumor
- adenocarcinoma
- hepatocellular carcinoma
- carcinoma
- liver neoplasm
- rheumatoid arthritis
- non-insulin-dependent diabetes mellitus
- pancreatic adenocarcinoma
- metastatic renal clear cell adenocarcinoma
role in cell
- expression in
- growth
- quantity
- cell death
- outgrowth
- activation in
- apoptosis
- migration
- phosphorylation in
- synthesis in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- cell surface
- Extracellular Space
- cellular membrane
- actin cytoskeleton
- Nucleus
- Mitochondria
- cytosol
- pedicels
- membrane rafts
- axons
- plasma
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human FLT1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- positive regulation of MAP kinase activity
- peptidyl-tyrosine phosphorylation
- multicellular organismal development
- positive regulation of cell proliferation
- vascular endothelial growth factor signaling pathway
- protein autophosphorylation
- blood vessel morphogenesis
- transmembrane receptor protein tyrosine kinase signaling pathway
- positive regulation of MAPK cascade
- positive regulation of angiogenesis
- vascular endothelial growth factor receptor signaling pathway
- embryonic morphogenesis
- monocyte chemotaxis
- angiogenesis
- cell differentiation
- positive regulation of kinase activity
- cellular response to vascular endothelial growth factor stimulus
- cell migration
- positive regulation of protein kinase B signaling cascade
- positive regulation of cell migration
Cellular Component
Where in the cell the gene product is active
- extracellular space
- endosome
- focal adhesion
- actin cytoskeleton
- receptor complex
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- ATP binding
- growth factor binding
- protein binding
- transmembrane receptor protein tyrosine kinase activity
- vascular endothelial growth factor-activated receptor activity