RNF4 Gene Summary [Human]
The protein encoded by this gene contains a RING finger motif and acts as a transcription regulator. This protein has been shown to interact with, and inhibit the activity of, TRPS1, a transcription suppressor of GATA-mediated transcription. Transcription repressor ZNF278/PATZ is found to interact with this protein, and thus reduce the enhancement of androgen receptor-dependent transcription mediated by this protein. Studies of the mouse and rat counterparts suggested a role of this protein in spermatogenesis. A pseudogene of this gene is found on chromosome 1.[provided by RefSeq, Jul 2010]
Details
| Type | Protein Coding |
| Official Symbol | RNF4 |
| Official Name | ring finger protein 4 [Source:HGNC Symbol;Acc:HGNC:10067] |
| Ensembl ID | ENSG00000063978 |
| Bio databases IDs | |
| Aliases | ring finger protein 4 |
| Synonyms | GTRGEO8, RES4-26, ring finger protein 4, SLX5, SNURF |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human RNF4 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- transcription regulator
- SUMO interaction motif
- zinc finger of C3HC4-type, RING
- ubiquitin protein ligase activity
- enzyme binding
- androgen receptor binding
- transcription factor binding
- chromatin binding
- Ring finger domain
- protein binding
- estrogen receptor binding
- identical protein binding
- DNA binding
- TATA-binding protein binding
- androgen receptor binding domain
- binding protein
- zinc ion binding
- RING-type zinc-finger
- Ring finger
- RING finger (Really Interesting New Gene) domain and U-box domain superfamily
- ubiquitin-protein transferase activity
- basic domain
- Zinc finger, C3HC4 type (RING finger)
- zinc-RING finger domain
Pathways
Biological processes and signaling networks where the RNF4 gene in human plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- epithelial cancer
- liver cancer
- liver neoplasia
- organismal death
- coronary artery disease
- osteosarcoma
- osteosarcomagenesis
- liposarcoma
- soft tissue sarcoma cancer
- severe acute respiratory syndrome
role in cell
- phosphorylation in
- radiosensitivity
- damage in
- proliferation
- survival
- disassembly
- apoptosis
- growth
- cell cycle progression
- cohesion
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- Cytoplasm
- nucleoplasm
- nuclear bodies
- nuclear matrix
- PML nuclear bodies
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human RNF4 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- protein K11-linked ubiquitination
- proteasomal ubiquitin-dependent protein catabolic process
- protein K48-linked ubiquitination
- regulation of kinetochore assembly
- positive regulation of transcription, DNA-dependent
- response to arsenic-containing substance
- regulation of spindle assembly
- protein K63-linked ubiquitination
- positive regulation of transcription from RNA polymerase II promoter
- protein K6-linked ubiquitination
- protein autoubiquitination
Cellular Component
Where in the cell the gene product is active
- nucleus
- nuclear body
- PML body
- cytoplasm
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- ubiquitin-protein ligase activity
- DNA binding
- identical protein binding
- zinc ion binding
- protein binding
- nucleosome binding
- SUMO polymer binding
- ligand-dependent nuclear receptor transcription coactivator activity
- transcription factor binding