CNTN6 Gene Summary [Human]
The protein encoded by this gene is a member of the immunoglobulin superfamily. It is a glycosylphosphatidylinositol (GPI)-anchored neuronal membrane protein that functions as a cell adhesion molecule. It may play a role in the formation of axon connections in the developing nervous system. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2014]
Details
| Type | Protein Coding |
| Official Symbol | CNTN6 |
| Official Name | contactin 6 [Source:HGNC Symbol;Acc:HGNC:2176] |
| Ensembl ID | ENSG00000134115 |
| Bio databases IDs | |
| Aliases | contactin 6, neural adhesion molecule |
| Synonyms | contactin 6, NB-3 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human CNTN6 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- extracellular domain
- FN3
- immunoglobulin domain
- Immunoglobulin like
- Immunoglobulin I-set domain
- enzyme
- protein binding
- Fibronectin type 3 domain
- Immunoglobulin V-set domain
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- presynaptic regions
- cell surface
- presynaptic membrane
- excitatory synapses
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human CNTN6 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- central nervous system development
- Notch signaling pathway
- synapse organization
- dendrite self-avoidance
- axon guidance
- cell adhesion
- homophilic cell adhesion
- positive regulation of Notch signaling pathway
Cellular Component
Where in the cell the gene product is active
- presynaptic membrane
- synapse
- axon
- plasma membrane