Cntn6 Gene Summary [Mouse]
Predicted to enable cell-cell adhesion mediator activity. Acts upstream of or within positive regulation of Notch signaling pathway. Located in plasma membrane. Is active in parallel fiber to Purkinje cell synapse and presynaptic membrane. Is expressed in brain; renal medulla; spinal cord; and tooth. Orthologous to human CNTN6 (contactin 6). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Cntn6 |
| Official Name | contactin 6 [Source:MGI Symbol;Acc:MGI:1858223] |
| Ensembl ID | ENSMUSG00000030092 |
| Bio databases IDs | |
| Aliases | contactin 6 |
| Synonyms | contactin 6, NB-3 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Cntn6 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- extracellular domain
- FN3
- immunoglobulin domain
- Immunoglobulin like
- Immunoglobulin I-set domain
- enzyme
- protein binding
- Fibronectin type 3 domain
- Immunoglobulin V-set domain
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- presynaptic regions
- cell surface
- presynaptic membrane
- excitatory synapses
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Cntn6 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- central nervous system development
- Notch signaling pathway
- synapse organization
- dendrite self-avoidance
- axon guidance
- cell adhesion
- homophilic cell adhesion
- positive regulation of Notch signaling pathway
Cellular Component
Where in the cell the gene product is active
- presynaptic membrane
- synapse
- axon
- plasma membrane