PTPRG Gene Summary [Human]
The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP possesses an extracellular region, a single transmembrane region, and two tandem intracytoplasmic catalytic domains, and thus represents a receptor-type PTP. The extracellular region of this PTP contains a carbonic anhydrase-like (CAH) domain, which is also found in the extracellular region of PTPRBETA/ZETA. This gene is located in a chromosomal region that is frequently deleted in renal cell carcinoma and lung carcinoma, thus is thought to be a candidate tumor suppressor gene. [provided by RefSeq, Jul 2008]
Details
| Type | Processed Transcript |
| Official Symbol | PTPRG |
| Official Name | protein tyrosine phosphatase receptor type G [Source:HGNC Symbol;Acc:HGNC:9671] |
| Ensembl ID | ENSG00000144724 |
| Bio databases IDs | |
| Aliases | protein tyrosine phosphatase receptor type G |
| Synonyms | 5430405N12RIK, AW046354, AW549872, HPTPG, protein tyrosine phosphatase receptor type G, protein tyrosine phosphatase, receptor type, G, PTPG, PTP-γ, RPTPG, R-PTP-GAMMA, R-PTP-γ |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human PTPRG often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- protein-tyrosine-phoshatase
- catalytic domain
- carbonic anhydrase domain
- Protein tyrosine phosphatase, catalytic domain
- alpha_CA
- Fibronectin type 3 domain
- PTP_DSP_cys
- protein binding
- identical protein binding
- Protein tyrosine phosphatase, catalytic domain motif
- Protein tyrosine phosphatase, catalytic domain, undefined specificity
- Protein-tyrosine phosphatase
- transmembrane receptor protein tyrosine phosphatase
- FN3
- Eukaryotic-type carbonic anhydrase
- phosphatase
Pathways
Biological processes and signaling networks where the PTPRG gene in human plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- osteoarthritis
- psoriasis
- metabolic syndrome X
- bipolar disorder
- stroke
- major depression
- COVID-19
- schizophrenia
- atopic dermatitis
- acute myeloid leukemia
role in cell
- growth
- proliferation
- phosphorylation in
- colony formation
- motility
- development
- survival
- migration by
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- detergent resistant lipid raft fraction
- Cytoplasm
- cell surface
- Extracellular Space
- cellular membrane
- photoreceptor outer segments
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human PTPRG gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of neuron projection development
- protein dephosphorylation
- negative regulation of epithelial cell migration
- transmembrane receptor protein tyrosine kinase signaling pathway
Cellular Component
Where in the cell the gene product is active
- extracellular vesicular exosome
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- identical protein binding
- protein binding
- protein tyrosine phosphatase activity
- transmembrane receptor protein tyrosine phosphatase activity