CHIA Gene Summary [Human]
The protein encoded by this gene degrades chitin, which is found in the cell wall of most fungi as well as in arthropods and some nematodes. The encoded protein can also stimulate interleukin 13 expression, and variations in this gene can lead to asthma susceptibility. Several transcript variants encoding a few different isoforms have been found for this gene. [provided by RefSeq, Apr 2012]
Details
| Type | Protein Coding |
| Official Symbol | CHIA |
| Official Name | chitinase acidic [Source:HGNC Symbol;Acc:HGNC:17432] |
| Ensembl ID | ENSG00000134216 |
| Bio databases IDs | |
| Aliases | chitinase acidic, acidic mammalian chitinase |
| Synonyms | AMCASE, CHIT2, chitinase acidic, TSA1902 |
| Species | Human, Homo sapiens |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human CHIA often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- chitinase
- kinase binding
- Glycosyl hydrolases family 18
- Chitin binding Peritrophin-A domain
- GH18_chitinase-like
- enzyme
- protein binding
- Glyco_18 domain
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- lung adenocarcinoma
- lung adenocarcinoma formation
- early-onset high myopia
- eosinophilic inflammation
role in cell
- apoptosis
- phosphorylation in
- production in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Extracellular Space
- Cytoplasm
- extracellular matrix
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human CHIA gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- production of molecular mediator involved in inflammatory response
- polysaccharide catabolic process
- chitin catabolic process
- chitin metabolic process
- apoptotic process
- polysaccharide digestion
- positive regulation of chemokine production
- immune system process
Cellular Component
Where in the cell the gene product is active
- extracellular space
- cytoplasm
- extracellular region
Molecular Function
What the gene product does at the molecular level
- chitinase activity
- chitin binding
- protein binding
- kinase binding