HELZ Gene Summary [Human]
HELZ is a member of the superfamily I class of RNA helicases. RNA helicases alter the conformation of RNA by unwinding double-stranded regions, thereby altering the biologic activity of the RNA molecule and regulating access to other proteins (Wagner et al., 1999 [PubMed 10471385]).[supplied by OMIM, Mar 2008]
Details
| Type | Protein Coding |
| Official Symbol | HELZ |
| Official Name | helicase with zinc finger [Source:HGNC Symbol;Acc:HGNC:16878] |
| Ensembl ID | ENSG00000198265 |
| Bio databases IDs | |
| Aliases | helicase with zinc finger, down-regulated in human cancers |
| Synonyms | 3110078M01RIK, 9430093I07RIK, 9630002H22Rik, AI851979, DHRC, DRHC, helicase with zinc finger, helicase with zinc finger domain, HUMORF5, LOC284019 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human HELZ often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Type III restriction enzyme, res subunit
- N-terminal helicase domain of the DEAD-box helicase superfamily
- enzyme
- Zinc finger C-x8-C-x5-C-x3-H type (and similar)
- protein binding
- P-loop containing Nucleoside Triphosphate Hydrolases
- AAA domain
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- epithelial cancer
- epithelial neoplasia
- cancer
- liver cancer
- cholangiocarcinoma cancer
- bile duct cancer
- liver neoplasia
- biliary tract cancer
- abdominal cancer
- digestive system cancer
regulated by
- GnRH analog
- SNCA
- mir-30 (includes others)
- curcumin
- T lymphocytes
- hematopoietic progenitor cells
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human HELZ gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- posttranscriptional gene silencing by RNA
Cellular Component
Where in the cell the gene product is active
- nucleus
- P granule
- membrane
- cytosol
Molecular Function
What the gene product does at the molecular level
- ATP binding
- protein binding
- RNA binding
- metal ion binding
- helicase activity
- hydrolase activity