HRH4 Gene Summary [Human]
Histamine is a ubiquitous messenger molecule released from mast cells, enterochromaffin-like cells, and neurons. Its various actions are mediated by a family of histamine receptors, which are a subset of the G-protein coupled receptor superfamily. This gene encodes a histamine receptor that is predominantly expressed in haematopoietic cells. The protein is thought to play a role in inflammation and allergy reponses. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2009]
Details
| Type | Protein Coding |
| Official Symbol | HRH4 |
| Official Name | histamine receptor H4 [Source:HGNC Symbol;Acc:HGNC:17383] |
| Ensembl ID | ENSG00000134489 |
| Bio databases IDs | |
| Aliases | histamine receptor H4 |
| Synonyms | AXOR35, BG26, GPCR105, GPRv53, H4, H4R, H4 receptor, HH4R, Histamine h4 receptor, histamine receptor H4, HR4, SP9144 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human HRH4 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- G-protein coupled receptor
- histamine receptor
- 7 transmembrane receptor (rhodopsin family)
- seven-transmembrane G protein-coupled receptor superfamily
Pathways
Biological processes and signaling networks where the HRH4 gene in human plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- streptozotocin-induced diabetic nephropathy
- nausea
- pruritus
- allergic rhinitis
- breast cancer
- early phase nasal response
- the common cold
- urticaria
- experimental autoimmune encephalomyelitis
- cough
role in cell
- binding
- migration
- function
- production in
- chemotaxis
- tubulation
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- plasma membrane fraction
- cell surface
- intracellular space
- cellular membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human HRH4 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- inflammatory response
- regulation of MAPK cascade
- adenylate cyclase-inhibiting G-protein coupled acetylcholine receptor signaling pathway
- G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger
- synaptic transmission
- elevation of cytosolic calcium ion concentration
Cellular Component
Where in the cell the gene product is active
- dendrite
- synapse
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- histamine receptor activity
- G-protein coupled acetylcholine receptor activity
- serotonin receptor activity