Hrh4 Gene Summary [Mouse]
Enables histamine receptor activity. Predicted to be involved in G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger; adenylate cyclase-inhibiting G protein-coupled acetylcholine receptor signaling pathway; and chemical synaptic transmission. Predicted to act upstream of or within inflammatory response. Located in membrane. Orthologous to human HRH4 (histamine receptor H4). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Hrh4 |
| Official Name | histamine receptor H4 [Source:MGI Symbol;Acc:MGI:2429635] |
| Ensembl ID | ENSMUSG00000037346 |
| Bio databases IDs | |
| Aliases | histamine receptor H4 |
| Synonyms | AXOR35, BG26, GPCR105, GPRv53, H4, H4R, H4 receptor, HH4R, Histamine h4 receptor, histamine receptor H4, HR4, SP9144 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Hrh4 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- G-protein coupled receptor
- histamine receptor
- 7 transmembrane receptor (rhodopsin family)
- seven-transmembrane G protein-coupled receptor superfamily
Pathways
Biological processes and signaling networks where the Hrh4 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
binds
- BILF1
- triprolidine
- tesmilifene
- buclizine
- aripiprazole
- histamine
- CCL16
- MAP4K1
disease
- streptozotocin-induced diabetic nephropathy
- nausea
- pruritus
- allergic rhinitis
- breast cancer
- early phase nasal response
- the common cold
- urticaria
- experimental autoimmune encephalomyelitis
- cough
role in cell
- binding
- migration
- function
- production in
- chemotaxis
- tubulation
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- plasma membrane fraction
- cell surface
- intracellular space
- cellular membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Hrh4 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- inflammatory response
- regulation of MAPK cascade
- adenylate cyclase-inhibiting G-protein coupled acetylcholine receptor signaling pathway
- G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger
- synaptic transmission
- elevation of cytosolic calcium ion concentration
Cellular Component
Where in the cell the gene product is active
- dendrite
- synapse
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- histamine receptor activity
- G-protein coupled acetylcholine receptor activity
- serotonin receptor activity