YARS1 Gene Summary [Human]
Aminoacyl-tRNA synthetases catalyze the aminoacylation of tRNA by their cognate amino acid. Because of their central role in linking amino acids with nucleotide triplets contained in tRNAs, aminoacyl-tRNA synthetases are thought to be among the first proteins that appeared in evolution. Tyrosyl-tRNA synthetase belongs to the class I tRNA synthetase family. Cytokine activities have also been observed for the human tyrosyl-tRNA synthetase, after it is split into two parts, an N-terminal fragment that harbors the catalytic site and a C-terminal fragment found only in the mammalian enzyme. The N-terminal fragment is an interleukin-8-like cytokine, whereas the released C-terminal fragment is an EMAP II-like cytokine. [provided by RefSeq, Jul 2008]
Details
| Type | Retained Intron |
| Official Symbol | YARS1 |
| Official Name | tyrosyl-tRNA synthetase 1 [Source:HGNC Symbol;Acc:HGNC:12840] |
| Ensembl ID | ENSG00000134684 |
| Bio databases IDs | |
| Aliases | tyrosyl-tRNA synthetase 1, tyrosine tRNA ligase 1, cytoplasmic |
| Synonyms | CMTDIC, IMNEPD2, tyrosyl-tRNA synthetase 1, TYRRS, tyrS, YARS, YRS, YTS |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human YARS1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- tRNA synthetases class I (W and Y)
- tyrosine-tRNA ligase
- methionyl-tRNA synthetase C-terminal region/beta chain
- enzyme
- protein binding
- tRNA_bindingDomain
- ELR motif
- tyrosyl-tRNA synthetase
- interleukin-8 receptor binding
- binding protein
- tryptophanyl-tRNA synthetase
- Putative tRNA binding domain
- nucleotidyl transferase superfamily
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- hearing loss
- infantile-onset multisystem neurologic, endocrine, and pancreatic disease type 2
- Charcot-Marie-Tooth disease, dominant intermediate type c
- infantile-onset multisystem neurologic, endocrine and pancreatic disease
- small cell lung cancer
- acute myeloid leukemia
- Charcot-Marie-Tooth disease
- hereditary disorder
- non-small cell lung cancer
role in cell
- growth
- cell death
- migration
- phosphorylation in
- apoptosis
- activation in
- formation
- length
- chemotaxis
- tubulation by
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Extracellular Space
- Nucleus
- granules
- cytosol
- nuclear bodies
- neurites
- filopodia
- axon terminals
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human YARS1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- tyrosyl-tRNA aminoacylation
- apoptotic process
- response to starvation
Cellular Component
Where in the cell the gene product is active
- nucleus
- extracellular space
- nuclear body
- cytoplasm
- cytosol
Molecular Function
What the gene product does at the molecular level
- tyrosine-tRNA ligase activity
- ATP binding
- RNA binding
- protein binding
- interleukin-8 receptor binding
- small molecule binding
- tRNA binding