STT3A Gene Summary [Human]
The protein encoded by this gene is a catalytic subunit of the N-oligosaccharyltransferase (OST) complex, which functions in the endoplasmic reticulum to transfer glycan chains to asparagine residues of target proteins. A separate complex containing a similar catalytic subunit with an overlapping function also exists. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2015]
Details
| Type | Protein Coding |
| Official Symbol | STT3A |
| Official Name | STT3 oligosaccharyltransferase complex catalytic subunit A [Source:HGNC Symbol;Acc:HGNC:6172] |
| Ensembl ID | ENSG00000134910 |
| Bio databases IDs | |
| Aliases | STT3 oligosaccharyltransferase complex catalytic subunit A, dolichyl-diphosphooligosaccharide protein glycotransferase |
| Synonyms | B5, CDG1WAD, CDG1WAR, ITM1, RGD1565793, STT3 oligosaccharyltransferase complex catalytic subunit A, STT3, subunit of the oligosaccharyltransferase complex, homolog A (S. cerevisiae), TMC |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human STT3A often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- dolichyl-diphosphooligosaccharide-protein glycotransferase
- Oligosaccharyl transferase STT3 subunit
- enzyme
- protein binding
- dolichyl-phosphate-mannose-protein mannosyltransferase
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- adenoma formation
- autosomal dominant congenital disorder of glycosylation type Iw
- schizophrenia
- pervasive developmental disorder
- major depression
- attention deficit hyperactivity disorder
- bipolar disorder
- congenital disorder of glycosylation type 1w
- aldosterone producing adrenocortical adenoma
- infection by HIV-1
regulates
- Myelin
- asparagine
- zymosan
- saposin
- F7
role in cell
- phagocytosis
- phagocytosis by
- glycosylation in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- pH resistant lipid raft fraction
- cellular membrane
- Nucleus
- Mitochondria
- endoplasmic reticulum membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human STT3A gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- protein N-linked glycosylation
- protein N-linked glycosylation via asparagine
- co-translational protein modification
- post-translational protein modification
Cellular Component
Where in the cell the gene product is active
- oligosaccharyltransferase III complex
- oligosaccharyltransferase complex
- endoplasmic reticulum membrane
- membrane
Molecular Function
What the gene product does at the molecular level
- dolichyl-diphosphooligosaccharide-protein glycotransferase activity
- protein binding
- metal ion binding