Stt3a Gene Summary [Mouse]
Predicted to enable dolichyl-diphosphooligosaccharide-protein glycotransferase activity. Predicted to be involved in co-translational protein modification; post-translational protein modification; and protein N-linked glycosylation via asparagine. Located in membrane. Is expressed in several structures, including craniocervical region bone and thoracic segment skeleton. Human ortholog(s) of this gene implicated in congenital disorder of glycosylation Iw. Orthologous to human STT3A (STT3 oligosaccharyltransferase complex catalytic subunit A). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Stt3a |
| Official Name | STT3, subunit of the oligosaccharyltransferase complex, homolog A (S. cerevisiae) [Source:MGI Symbol;Acc:MGI:105124] |
| Ensembl ID | ENSMUSG00000032116 |
| Bio databases IDs | |
| Aliases | STT3, subunit of the oligosaccharyltransferase complex, homolog A (S. cerevisiae) |
| Synonyms | B5, CDG1WAD, CDG1WAR, ITM1, RGD1565793, STT3 oligosaccharyltransferase complex catalytic subunit A, STT3, subunit of the oligosaccharyltransferase complex, homolog A (S. cerevisiae), TMC |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Stt3a often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- dolichyl-diphosphooligosaccharide-protein glycotransferase
- Oligosaccharyl transferase STT3 subunit
- enzyme
- protein binding
- dolichyl-phosphate-mannose-protein mannosyltransferase
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- adenoma formation
- autosomal dominant congenital disorder of glycosylation type Iw
- schizophrenia
- pervasive developmental disorder
- major depression
- attention deficit hyperactivity disorder
- bipolar disorder
- congenital disorder of glycosylation type 1w
- aldosterone producing adrenocortical adenoma
- infection by HIV-1
regulates
- Myelin
- asparagine
- zymosan
- saposin
- F7
role in cell
- phagocytosis
- phagocytosis by
- glycosylation in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- pH resistant lipid raft fraction
- cellular membrane
- Nucleus
- Mitochondria
- endoplasmic reticulum membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Stt3a gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- protein N-linked glycosylation
- protein N-linked glycosylation via asparagine
- co-translational protein modification
- post-translational protein modification
Cellular Component
Where in the cell the gene product is active
- oligosaccharyltransferase III complex
- oligosaccharyltransferase complex
- endoplasmic reticulum membrane
- membrane
Molecular Function
What the gene product does at the molecular level
- dolichyl-diphosphooligosaccharide-protein glycotransferase activity
- protein binding
- metal ion binding