LACRT Gene Summary [Human]
The protein encoded by this gene is highly expressed in the lacrimal glands and localized primarily to secretory granules and secretory fluid. It augments lacrimal acinar cell secretion, promotes ductal cell proliferation, and stimulates signaling through tyrosine phosphorylation and release of calcium. [provided by RefSeq, Jul 2008]
Details
| Type | Protein Coding |
| Official Symbol | LACRT |
| Official Name | lacritin [Source:HGNC Symbol;Acc:HGNC:16430] |
| Ensembl ID | ENSG00000135413 |
| Bio databases IDs | |
| Aliases | lacritin |
| Synonyms | LACRITIN |
| Species | Human, Homo sapiens |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human LACRT often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- laminin binding
- collagen binding
- protein binding
- growth factor
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Extracellular Space
- secretory granules
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human LACRT gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- calcineurin-NFAT signaling cascade
- positive regulation of macroautophagy
- protein localization in Golgi apparatus
- positive regulation of epithelial cell proliferation involved in wound healing
- positive regulation of cell proliferation
- positive regulation of release of sequestered calcium ion into cytosol
- defense response to bacterium
- positive regulation of calcium-mediated signaling
- tear secretion
- positive regulation of secretion
- epithelial structure maintenance
- negative regulation of apoptotic process
- positive regulation of calcineurin-NFAT signaling cascade
- calcium-mediated signaling
- positive regulation of epithelial cell proliferation
- positive regulation of peptidyl-tyrosine phosphorylation
- negative regulation of lipopolysaccharide-mediated signaling pathway
Cellular Component
Where in the cell the gene product is active
- extracellular space
- secretory granule
- extracellular region
Molecular Function
What the gene product does at the molecular level
- growth factor activity
- protein binding
- collagen binding
- laminin-1 binding