POLL Gene Summary [Human]
This gene encodes a DNA polymerase. DNA polymerases catalyze DNA-template-directed extension of the 3'-end of a DNA strand. This particular polymerase, which is a member of the X family of DNA polymerases, likely plays a role in non-homologous end joining and other DNA repair processes. Alternatively spliced transcript variants have been described. [provided by RefSeq, Mar 2010]
Details
| Type | Processed Transcript |
| Official Symbol | POLL |
| Official Name | DNA polymerase lambda [Source:HGNC Symbol;Acc:HGNC:9184] |
| Ensembl ID | ENSG00000166169 |
| Bio databases IDs | |
| Aliases | DNA polymerase lambda |
| Synonyms | 1110003P06Rik, BETAN, DNA polymerase lambda, DNA polymerase λ, POLKAPPA, polymerase (DNA directed), lambda, polymerase (DNA directed), λ, Pol-κ, β-n |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human POLL often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Helix-hairpin-helix domain
- BRCT
- DNA polymerase beta thumb
- DNA-directed DNA polymerase
- Nucleotidyltransferase (NT) domain of DNA polymerase beta and similar proteins
- Fingers domain of DNA polymerase lambda
- DNA polymerase X family
- enzyme
- protein binding
- DNA polymerase beta palm
- carbon-oxygen lyase
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- chronic suppurative sinusitis
- situs inversus totalis
- hydrocephalus
- infection by HIV
regulates
- nucleotide
- DNA polymerase
- POLL
- 5'-deoxyribose phosphate
- adenine
role in cell
- cell viability
- proliferation
- cell movement
- quantity
- differentiation
- number
- growth
- replication
- morphology
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- nuclear foci
- nucleoplasm
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human POLL gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- DNA replication
- DNA biosynthetic process
- double-strand break repair via homologous recombination
- nucleotide-excision repair
- base-excision repair, gap-filling
- double-strand break repair via nonhomologous end joining
- somatic hypermutation of immunoglobulin genes
Cellular Component
Where in the cell the gene product is active
- nucleus
- site of double-strand break
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- DNA binding
- DNA-directed DNA polymerase activity
- 5'-deoxyribose-5-phosphate lyase activity
- protein binding
- metal ion binding