NTPCR Gene Summary [Human]
The protein encoded by this gene is a non-specific nucleoside triphosphatase that is slow-acting in vitro. This gene is overexpressed in many tumor tissues, and while it is not essential for the cell, overexpression is cytotoxic. However, the cytotoxicity is not related to its triphosphatase activity. [provided by RefSeq, Jul 2016]
Details
| Type | Processed Transcript |
| Official Symbol | NTPCR |
| Official Name | nucleoside-triphosphatase, cancer-related [Source:HGNC Symbol;Acc:HGNC:28204] |
| Ensembl ID | ENSG00000135778 |
| Bio databases IDs | |
| Aliases | nucleoside-triphosphatase, cancer-related, human cancer-related NTPase |
| Synonyms | 2310079N02Rik, C1orf57, HCR-NTPase, nucleoside-triphosphatase, cancer-related, RGD1306192, THEP1 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human NTPCR often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- nucleoside-triphosphatase
- AAA ATPase domain
- enzyme
- NTPase
- P-loop containing Nucleoside Triphosphate Hydrolases
- AAA domain
- ATPases associated with a variety of cellular activities
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Mitochondria
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human NTPCR gene, providing context for its role in the cell.
Cellular Component
Where in the cell the gene product is active
- membrane
Molecular Function
What the gene product does at the molecular level
- ATPase activity
- ATP binding
- RNA binding
- CTPase activity
- GTPase activity
- nucleoside-triphosphatase activity