THSD1 Gene Summary [Human]
The protein encoded by this gene contains a type 1 thrombospondin domain, which is found in a number of proteins involved in the complement pathway, as well as in extracellular matrix proteins. Alternatively spliced transcript variants encoding different isoforms have been observed for this gene. [provided by RefSeq, Jan 2009]
Details
| Type | Protein Coding |
| Official Symbol | THSD1 |
| Official Name | thrombospondin type 1 domain containing 1 [Source:HGNC Symbol;Acc:HGNC:17754] |
| Ensembl ID | ENSG00000136114 |
| Bio databases IDs | |
| Aliases | thrombospondin type 1 domain containing 1 |
| Synonyms | 4833423O18Rik, ANIB12, LMPHM13, thrombospondin type 1 domain containing 1, thrombospondin, type I, domain 1, TMTSP, UNQ3010 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human THSD1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Thrombospondin type 1 repeats
- Thrombospondin type 1 domain
- extracellular matrix binding
- protein binding
- Spondin-like TSP1 domain
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Extracellular Space
- Cytoplasm
- cell surface
- cell periphery
- focal adhesions
- endosomes
- cytosol
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human THSD1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- focal adhesion assembly
Cellular Component
Where in the cell the gene product is active
- endosome
- focal adhesion
- cytosol
- endosome membrane
- extracellular region
- cell periphery
Molecular Function
What the gene product does at the molecular level
- extracellular matrix binding
- protein binding