OGA Gene Summary [Human]
The dynamic modification of cytoplasmic and nuclear proteins by O-linked N-acetylglucosamine (O-GlcNAc) addition and removal on serine and threonine residues is catalyzed by OGT (MIM 300255), which adds O-GlcNAc, and MGEA5, a glycosidase that removes O-GlcNAc modifications (Gao et al., 2001 [PubMed 11148210]).[supplied by OMIM, Mar 2008]
Details
| Type | Protein Coding |
| Official Symbol | OGA |
| Official Name | O-GlcNAcase [Source:HGNC Symbol;Acc:HGNC:7056] |
| Ensembl ID | ENSG00000198408 |
| Bio databases IDs | |
| Aliases | O-GlcNAcase, nuclear cytoplasmic O-GlcNAcase and acetyltransferase |
| Synonyms | Hy5,LOC108349825,MEA5,MGEA5,N-Acetyl-beta-D-glucosaminidase,N-Acetyl-β-D-glucosaminidase,NCOAT,OGAse,O-GlcNAcase |
| Species | Human, Homo sapiens |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human OGA often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- histone acetyltransferase
- glycosidase
- enzyme
- protein binding
- beta-N-acetylglucosaminidase
- hyalurononglucosaminidase
- identical protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- adenoma formation
- breast cancer
- colon cancer
- hyperleptinemia
- Alzheimer disease
- pervasive developmental disorder
- corticotrophic adenoma
- head and neck neuroendocrine neoplasia
- lung cancer
role in cell
- phosphorylation in
- apoptosis
- expression in
- killing
- growth
- binding in
- transmembrane potential
- morphology
- non-clathrin endocytosis by
- O-GlcNAcylation in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- ribosome
- Nucleus
- lipid droplets
- cytosol
- nucleoplasm
- nucleoli
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human OGA gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- glycoprotein catabolic process
- protein deglycosylation
- protein O-linked glycosylation
- glycoprotein metabolic process
- N-acetylglucosamine metabolic process
Cellular Component
Where in the cell the gene product is active
- nucleus
- membrane
- cytosol
Molecular Function
What the gene product does at the molecular level
- identical protein binding
- hyalurononglucosaminidase activity
- beta-N-acetylglucosaminidase activity