Thsd1 Gene Summary [Mouse]
Predicted to enable extracellular matrix binding activity. Acts upstream of or within hematopoietic progenitor cell differentiation. Located in cell periphery; cell surface; and cytoplasm. Is expressed in several structures, including alimentary system; cardiovascular system; genitourinary system; immune system; and nervous system. Human ortholog(s) of this gene implicated in hereditary lymphedema and intracranial berry aneurysm 12. Orthologous to human THSD1 (thrombospondin type 1 domain containing 1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Thsd1 |
| Official Name | thrombospondin, type I, domain 1 [Source:MGI Symbol;Acc:MGI:1929096] |
| Ensembl ID | ENSMUSG00000031480 |
| Bio databases IDs | |
| Aliases | thrombospondin, type I, domain 1 |
| Synonyms | 4833423O18Rik, ANIB12, LMPHM13, thrombospondin type 1 domain containing 1, thrombospondin, type I, domain 1, TMTSP, UNQ3010 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Thsd1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Thrombospondin type 1 repeats
- Thrombospondin type 1 domain
- extracellular matrix binding
- protein binding
- Spondin-like TSP1 domain
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Extracellular Space
- Cytoplasm
- cell surface
- cell periphery
- focal adhesions
- endosomes
- cytosol
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Thsd1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- focal adhesion assembly
Cellular Component
Where in the cell the gene product is active
- endosome
- focal adhesion
- cytosol
- endosome membrane
- extracellular region
- cell periphery
Molecular Function
What the gene product does at the molecular level
- extracellular matrix binding
- protein binding