CCN3 Gene Summary [Human]
The protein encoded by this gene is a small secreted cysteine-rich protein and a member of the CCN family of regulatory proteins. CNN family proteins associate with the extracellular matrix and play an important role in cardiovascular and skeletal development, fibrosis and cancer development. [provided by RefSeq, Feb 2009]
Details
| Type | Protein Coding |
| Official Symbol | CCN3 |
| Official Name | cellular communication network factor 3 [Source:HGNC Symbol;Acc:HGNC:7885] |
| Ensembl ID | ENSG00000136999 |
| Bio databases IDs | |
| Aliases | cellular communication network factor 3 |
| Synonyms | C130088N23Rik, cellular communication network factor 3, IBP-9, IGFBP-9, IGFBP-RP3, NOV, NOVH |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human CCN3 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Glycoprotein hormone beta chain homologues
- von Willebrand factor type C domain
- thrombospondin-1 motif
- integrin binding
- hormone
- protein binding
- Spondin-like TSP1 domain
- Insulin-like growth factor binding protein
- growth factor
- cysteine rich domain
- notch binding
- IGFBP-like domain
Pathways
Biological processes and signaling networks where the CCN3 gene in human plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- osteopenia
- neoplasia
- metastasis
- congestion
- pancreatic ductal adenocarcinoma
- pancreatic epithelial cancer
- ductal pancreatic cancer
- venoocclusion
- cataract disease
- HER2 negative hormone receptor negative breast cancer
role in cell
- expression in
- proliferation
- survival
- phosphorylation in
- chemotaxis
- apoptosis
- transcription in
- function
- formation
- growth
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Extracellular Space
- intracellular membrane-bounded organelle
- Cytoplasm
- cell periphery
- perinuclear region
- Nucleus
- cytosol
- gap junction plaques
- gap junctions
- secretory granules
- extracellular matrix
- perikaryon
- axons
- dendrites
- exosomes
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human CCN3 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of monocyte chemotaxis
- negative regulation of SMAD protein import into nucleus
- signal transduction
- negative regulation of inflammatory response
- chondrocyte differentiation
- positive regulation of cell differentiation
- cell adhesion
- negative regulation of insulin secretion
- positive regulation of Notch signaling pathway
- smooth muscle cell proliferation
- cell chemotaxis
- smooth muscle cell migration
- cell adhesion mediated by integrin
- angiogenesis
- negative regulation of cell growth
- type B pancreatic cell proliferation
- regulation of gene expression
- endothelial cell chemotaxis
- negative regulation of myotube differentiation
- fibroblast migration
- endothelial cell-cell adhesion
Cellular Component
Where in the cell the gene product is active
- gap junction
- dendrite
- extracellular space
- cytoplasm
- intracellular membrane-bounded organelle
- extracellular matrix
- neuronal cell body
- extracellular region
- axon
Molecular Function
What the gene product does at the molecular level
- growth factor activity
- protein binding
- integrin binding
- Notch binding
- heparin binding