SERPINE1 Gene Summary [Human]
This gene encodes a member of the serine proteinase inhibitor (serpin) superfamily. This member is the principal inhibitor of tissue plasminogen activator (tPA) and urokinase (uPA), and hence is an inhibitor of fibrinolysis. The protein also functions as a component of innate antiviral immunity. Defects in this gene are the cause of plasminogen activator inhibitor-1 deficiency (PAI-1 deficiency), and high concentrations of the gene product are associated with thrombophilia. [provided by RefSeq, Aug 2020]
Details
| Type | Protein Coding |
| Official Symbol | SERPINE1 |
| Official Name | serpin family E member 1 [Source:HGNC Symbol;Acc:HGNC:8583] |
| Ensembl ID | ENSG00000106366 |
| Bio databases IDs | |
| Aliases | serpin family E member 1, plasminogen activator inhibitor, type I |
| Synonyms | beta MIGRATING PLAS ACTIVATOR, beta-MIGRATING PLASMINOGEN ACTIVATOR INHIBITOR I, PAI, PAI-1, PAI1A, Pai1aa, Planh, PLANH1, Plasminogen activator inhibitor 1, RATPAI1A, serine (or cysteine) peptidase inhibitor, clade E, member 1, SERPINE, serpin family E member 1, β MIGRATING PLAS ACTIVATOR, β-MIGRATING PLASMINOGEN ACTIVATOR INHIBITOR I |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human SERPINE1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- endopeptidase inhibitor
- activation domain
- protease binding
- SERine Proteinase INhibitors (serpin) family
- serine protease inhibitor activity
- protein binding
- receptor binding
- Serpin (serine protease inhibitor)
- reactive serpin loop
Pathways
Biological processes and signaling networks where the SERPINE1 gene in human plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- head and neck squamous cell carcinoma
- COVID-19
- kidney disease
- heart failure
- atherosclerosis
- sepsis
- diabetes mellitus
- non-insulin-dependent diabetes mellitus
- systemic sclerosis
- neoplasia
role in cell
- expression in
- cell viability
- migration
- phosphorylation in
- proliferation
- invasion by
- survival
- growth
- cell death
- deposition in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Extracellular Space
- polyribosome fractions
- cell surface
- intracellular space
- ribosome
- Nucleus
- Plasma Membrane
- Golgi Apparatus
- alpha granules
- extracellular matrix
- cell membrane leading edge
- chromaffin vesicles
- exosomes
- plasma
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human SERPINE1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- positive regulation of blood coagulation
- replicative senescence
- negative regulation of blood coagulation
- fibrinolysis
- positive regulation of angiogenesis
- dentinogenesis
- negative regulation of plasminogen activation
- angiogenesis
- negative regulation of endopeptidase activity
- negative regulation of smooth muscle cell migration
- negative regulation of endothelial cell apoptotic process
- positive regulation of receptor-mediated endocytosis
- negative regulation of wound healing
- negative regulation of smooth muscle cell-matrix adhesion
- negative regulation of fibrinolysis
- defense response to Gram-negative bacterium
- positive regulation of leukotriene production involved in inflammatory response
- positive regulation of monocyte chemotaxis
- positive regulation of inflammatory response
- negative regulation of vascular wound healing
- negative regulation of cell adhesion mediated by integrin
- positive regulation of interleukin-8 production
- cellular response to lipopolysaccharide
- regulation of receptor activity
- negative regulation of cell migration
Cellular Component
Where in the cell the gene product is active
- platelet alpha granule lumen
- extracellular space
- extracellular vesicular exosome
- serine protease inhibitor complex
- extracellular region
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- serine-type endopeptidase inhibitor activity
- protein binding
- protease binding
- receptor binding