CCN2 Gene Summary [Human]
The protein encoded by this gene is a mitogen that is secreted by vascular endothelial cells. The encoded protein plays a role in chondrocyte proliferation and differentiation, cell adhesion in many cell types, and is related to platelet-derived growth factor. Certain polymorphisms in this gene have been linked with a higher incidence of systemic sclerosis. [provided by RefSeq, Nov 2009]
Details
| Type | Protein Coding |
| Official Symbol | CCN2 |
| Official Name | cellular communication network factor 2 [Source:HGNC Symbol;Acc:HGNC:2500] |
| Ensembl ID | ENSG00000118523 |
| Bio databases IDs | |
| Aliases | cellular communication network factor 2 |
| Synonyms | AMPHIROGULIN, cellular communication network factor 2, CTGF, CTGF isoform 1, CTGRP, Fibroblast-inducible secreted, Fisp12, HCS24, IBP-8, IGFBP8, IGFBP-RP2, NOV2, Tissue growth factor |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human CCN2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Thrombospondin type 1 repeats
- Glycoprotein hormone beta chain homologues
- thrombospondin-1 motif
- heparin binding domain
- insulin-like growth factor binding
- protein binding
- fibronectin binding
- growth factor
- von Willebrand factor type C domain
- integrin binding
- Spondin-like TSP1 domain
- Insulin-like growth factor binding protein
- heparin binding
Pathways
Biological processes and signaling networks where the CCN2 gene in human plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- albuminuria
- epithelial cancer
- epithelial neoplasia
- cancer
- retroperitoneal cancer
- abdominal cancer
- COVID-19
- non-insulin-dependent diabetes mellitus
- infection
role in cell
- cell viability
- expression in
- phosphorylation in
- activation
- proliferation
- function
- activation in
- cell death
- apoptosis
- migration
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Extracellular Space
- membrane fraction
- intracellular membrane-bounded organelle
- cell periphery
- perinuclear region
- cell cortex
- Plasma Membrane
- Golgi Apparatus
- extracellular matrix
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human CCN2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- cell-matrix adhesion
- signal transduction
- regulation of chondrocyte differentiation
- chondrocyte differentiation
- epidermis development
- response to wounding
- fibroblast growth factor receptor signaling pathway
- positive regulation of cell differentiation
- cell adhesion
- tissue homeostasis
- reactive oxygen species metabolic process
- negative regulation of gene expression
- integrin-mediated signaling pathway
- cartilage condensation
- ossification
- positive regulation of stress fiber assembly
- angiogenesis
- positive regulation of JNK cascade
- positive regulation of ERK1 and ERK2 cascade
- DNA biosynthetic process
- chondrocyte proliferation
- cell migration
- lung development
Cellular Component
Where in the cell the gene product is active
- extracellular space
- intracellular membrane-bounded organelle
- Golgi apparatus
- extracellular matrix
- extracellular region
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- protein binding
- heparin binding
- integrin binding
- insulin-like growth factor binding