S100A4 Gene Summary [Human]
The protein encoded by this gene is a member of the S100 family of proteins containing 2 EF-hand calcium-binding motifs. S100 proteins are localized in the cytoplasm and/or nucleus of a wide range of cells, and involved in the regulation of a number of cellular processes such as cell cycle progression and differentiation. S100 genes include at least 13 members which are located as a cluster on chromosome 1q21. This protein may function in motility, invasion, and tubulin polymerization. Chromosomal rearrangements and altered expression of this gene have been implicated in tumor metastasis. Multiple alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq, Jul 2008]
Details
| Type | Protein Coding |
| Official Symbol | S100A4 |
| Official Name | S100 calcium binding protein A4 [Source:HGNC Symbol;Acc:HGNC:10494] |
| Ensembl ID | ENSG00000196154 |
| Bio databases IDs | |
| Aliases | S100 calcium binding protein A4, fibroblast-specific protein-1, calvasculin, murine placental homolog |
| Synonyms | 18A2, 42A, CAPL, FSP1, metastasin, MTS1, P9KA, PEL98, pk9a, Placental Calcium-Binding, RNP9KA, S100 calcium-binding protein A4 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human S100A4 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- EF-Hand
- calcium-dependent protein binding
- S-100/ICaBP type calcium binding domain
- dimerization domain
- binding protein
- chemoattractant
- actin binding
- calcium ion binding
- EFh
- protein binding
- receptor binding
- identical protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- epithelial cancer
- abdominal cancer
- epithelial neoplasia
- urogenital cancer
- cancer
- metastasis
- metastatic colorectal cancer
- adenoma formation
- liver neoplasia
- benign neoplasia
role in cell
- proliferation
- cell viability
- phosphorylation in
- apoptosis
- activation in
- growth
- migration
- expression in
- stabilization in
- differentiation
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- cell surface
- Extracellular Space
- perinuclear region
- Nucleus
- cytosol
- plasma membrane projections
- nucleoplasm
- perinuclear space
- nucleoli
- actin stress fibers
- cell membrane leading edge
- plasma
- lamellipodia
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human S100A4 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- positive chemotaxis
- positive regulation of I-kappaB kinase/NF-kappaB cascade
- epithelial to mesenchymal transition
Cellular Component
Where in the cell the gene product is active
- nucleus
- extracellular space
- perinuclear region of cytoplasm
- extracellular vesicular exosome
- cytosol
- extracellular region
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- transition metal ion binding
- identical protein binding
- RNA binding
- protein binding
- actin binding
- calcium ion binding
- calcium-dependent protein binding
- chemoattractant activity
- RAGE receptor binding