PIM1 Gene Summary [Human]
The protein encoded by this gene belongs to the Ser/Thr protein kinase family, and PIM subfamily. This gene is expressed primarily in B-lymphoid and myeloid cell lines, and is overexpressed in hematopoietic malignancies and in prostate cancer. It plays a role in signal transduction in blood cells, contributing to both cell proliferation and survival, and thus provides a selective advantage in tumorigenesis. Both the human and orthologous mouse genes have been reported to encode two isoforms (with preferential cellular localization) resulting from the use of alternative in-frame translation initiation codons, the upstream non-AUG (CUG) and downstream AUG codons (PMIDs:16186805, 1825810).[provided by RefSeq, Aug 2011]
Details
| Type | Protein Coding |
| Official Symbol | PIM1 |
| Official Name | Pim-1 proto-oncogene, serine/threonine kinase [Source:HGNC Symbol;Acc:HGNC:8986] |
| Ensembl ID | ENSG00000137193 |
| Bio databases IDs | |
| Aliases | Pim-1 proto-oncogene, serine/threonine kinase |
| Synonyms | PIM, Pim-1 proto-oncogene, serine/threonine kinase, proviral integration site 1 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human PIM1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- protein serine/threonine kinase
- Protein kinase (unclassified specificity)
- ATP-binding domain
- Protein tyrosine and serine/threonine kinase
- ATP binding
- transcription factor binding
- protein binding
- Protein kinase domain
- proline rich domain
- kinase
- protein kinase activator
- Serine/Threonine protein kinases, catalytic domain
- ATP-binding pocket
- kinase domain
- Protein Kinases, catalytic domain
- alcohol group acceptor phosphotransferase
- manganese ion binding
- Tyrosine kinase, catalytic domain
- ribosomal small subunit binding
Pathways
Biological processes and signaling networks where the PIM1 gene in human plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- diffuse large B-cell lymphoma
- epithelial cancer
- acute myocardial infarction
- neoplasia
- cancer
- growth failure
- COVID-19
- non-Hodgkin lymphoma
- non-Hodgkin disease
- Richter syndrome
role in cell
- expression in
- proliferation
- migration
- accumulation in
- invasion by
- stabilization in
- phosphorylation in
- translation in
- cell cycle progression
- differentiation
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- nuclear fraction
- spindle apparatus
- perichromosomal region
- cellular membrane
- Nucleus
- Plasma Membrane
- centriole
- cytosol
- nuclear foci
- nucleoplasm
- nucleoli
- spindle pole
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human PIM1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- positive regulation of cardiac muscle cell proliferation
- positive regulation of brown fat cell differentiation
- regulation of transmembrane transporter activity
- protein autophosphorylation
- negative regulation of sequence-specific DNA binding transcription factor activity
- protein phosphorylation
- negative regulation of innate immune response
- positive regulation of transcription, DNA-dependent
- negative regulation of apoptotic process
- vitamin D receptor signaling pathway
- apoptotic process
- cellular response to interferon-gamma
- protein stabilization
Cellular Component
Where in the cell the gene product is active
- nucleus
- cytoplasm
- cytosol
- nucleolus
- plasma membrane
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- ATP binding
- protein binding
- ribosomal small subunit binding
- manganese ion binding
- transcription factor binding
- protein serine/threonine kinase activity