PPP2R5B Gene Summary [Human]
The product of this gene belongs to the phosphatase 2A regulatory subunit B family. Protein phosphatase 2A is one of the four major Ser/Thr phosphatases, and it is implicated in the negative control of cell growth and division. It consists of a common heteromeric core enzyme, which is composed of a catalytic subunit and a constant regulatory subunit, that associates with a variety of regulatory subunits. The B regulatory subunit might modulate substrate selectivity and catalytic activity. This gene encodes a beta isoform of the regulatory subunit B56 subfamily. [provided by RefSeq, Jul 2008]
Details
| Type | Processed Transcript |
| Official Symbol | PPP2R5B |
| Official Name | protein phosphatase 2 regulatory subunit B'beta [Source:HGNC Symbol;Acc:HGNC:9310] |
| Ensembl ID | ENSG00000068971 |
| Bio databases IDs | |
| Aliases | protein phosphatase 2 regulatory subunit B'beta, PP2A, B subunit, B' beta isoform, PP2A, B subunit, B56 beta isoform, PP2A, B subunit, PR61 beta isoform, PP2A, B subunit, R5 beta isoform, serine/threonine protein phosphatase 2A, 56 kDa regulatory subunit, beta isoform |
| Synonyms | B56B, B56beta, B'beta, B'β, Pp2a b'beta, Pp2a b'β, PR61B, protein phosphatase 2 regulatory subunit B'beta, protein phosphatase 2, regulatory subunit B', beta, protein phosphatase 2 regulatory subunit B'β, protein phosphatase 2, regulatory subunit B', β |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human PPP2R5B often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- phosphatase
- protein phosphatase regulator
- Protein phosphatase 2A regulatory B subunit (B56 family)
- protein binding
Pathways
Biological processes and signaling networks where the PPP2R5B gene in human plays a role, providing insight into its function and relevance in health or disease.
- AMPK Signaling
- ATM Signaling
- Autophagy
- Cardiac β-adrenergic Signaling
- CDK5 Signaling
- Cell Cycle Regulation by BTG Family Proteins
- Ceramide Signaling
- Cyclins and Cell Cycle Regulation
- Dopamine Receptor Signaling
- Dopamine-DARPP32 Feedback in cAMP Signaling
- ERK/MAPK Signaling
- HIPPO signaling
- ILK Signaling
- Mitotic Roles of Polo-Like Kinase
- mTOR Signaling
- Production of Nitric Oxide and Reactive Oxygen Species in Macrophages
- Regulation of eIF4 and p70S6K Signaling
- Role of CHK Proteins in Cell Cycle Checkpoint Control
- Role of Tissue Factor in Cancer
- Telomerase Signaling
- Tight Junction Signaling
- WNT/β-catenin Signaling
- Xenobiotic Metabolism Signaling
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- heart failure
role in cell
- activation in
- phosphorylation in
- expression in
- growth
- cell cycle progression
- development
- tyrosine autophosphorylation in
- ubiquitination in
- growth in
- dephosphorylation in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- cytosol
- dendritic spines
- perikaryon
- dendritic shafts
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human PPP2R5B gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- regulation of peptidyl-tyrosine phosphorylation
- positive regulation of nerve growth factor receptor signaling pathway
- signal transduction
- cellular response to growth factor stimulus
- protein dephosphorylation
- positive regulation of neuron projection development
- negative regulation of G0 to G1 transition
- positive regulation of transcription from RNA polymerase II promoter
- regulation of protein autophosphorylation
- positive regulation of protein complex assembly
Cellular Component
Where in the cell the gene product is active
- nucleus
- cytoplasm
- cytosol
- protein phosphatase type 2A complex
Molecular Function
What the gene product does at the molecular level
- protein binding
- protein phosphatase activator activity
- protein phosphatase regulator activity